Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | NQO1 | P15559 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | ACACB | O00763 | 4/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8867157 | 0.86 | LMNA (0.51) | LMNAALDH1A1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL3832407 | 0.78 | ALDH1A1 (0.77) | LMNAALDH1A1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL11929142 | 0.78 | LMNA (0.52) | LMNAALDH1A1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL8866953 | 0.78 | ALDH1A1 (0.49) | LMNAALDH1A1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL8006543 | 0.77 | PARP10 (0.58) | LMNAALDH1A1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL12083098 | 0.76 | MLYCD (0.42) | LMNAALDH1A1MAPTSMN1; SMN2HTT | |
| SCHEMBL7497496 | 0.74 | KMT2A (0.46) | LMNASMN1; SMN2POLBL3MBTL1HTT | |
| SCHEMBL5743825 | 0.73 | PARP10 (0.58) | LMNAALDH1A1SMN1; SMN2L3MBTL1NQO1 | |
| SCHEMBL7417927 | 0.73 | NQO1 (0.50) | LMNAALDH1A1POLBNQO1PARP10 | |
| SCHEMBL9872013 | 0.73 | NQO1 (0.54) | LMNAALDH1A1MAPTMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614637-A | Process for preparing 1,3-dialkyl-5-hydroxyoxindoles and the ether derivatives thereof | BOEHRINGER INGELHEIM KG (DE) | 1997-03-25 | — | — | US | disclosed |