Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | NQO1 | P15559 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.49 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846597 | 0.84 | PARP10 (0.59) | PARP10ALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL3832407 | 0.84 | ALDH1A1 (0.77) | PARP10ALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL21399403 | 0.83 | SMN1; SMN2 (0.46) | ALDH1A1LMNAMAPTMAPK1POLB | |
| SCHEMBL10548607 | 0.81 | PARP10 (0.56) | PARP10ALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL7615944 | 0.79 | CA1 (0.53) | PARP10ALDH1A1MAPTSMN1; SMN2MAOB | |
| SCHEMBL8415852 | 0.79 | PARP10 (0.54) | PARP10ALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL9872013 | 0.78 | NQO1 (0.54) | PARP10ALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL8867764 | 0.77 | LMNA (0.52) | PARP10ALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL11929142 | 0.77 | LMNA (0.52) | PARP10ALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL8867157 | 0.76 | LMNA (0.51) | PARP10ALDH1A1LMNAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858455-A4 | 4-OXA AND 4-THIA STEROIDS | MERCK & CO INC (US) | 2000-04-12 | — | — | EP | claimed |
| EP-0858455-A1 | 4-OXA AND 4-THIA STEROIDS | Merck & Co., Inc. (US) | 1998-08-19 | — | — | EP | claimed |
| WO-1997015564-A1 | 4-OXA AND 4-THIA STEROIDS | MERCK & CO., INC. (US) | 1997-05-01 | — | — | WO | claimed |
| WO-1997015305-A1 | TREATMENT OF HYPERANDROGENIC CONDITIONS | MERCK & CO., INC. (US) | 1997-05-01 | — | — | WO | disclosed |