Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8869693 | 0.91 | HSD17B10 (0.50) | ALDH1A1HSD17B10HTTSMN1; SMN2LMNA | |
| SCHEMBL8868847 | 0.91 | ALDH1A1 (0.48) | ALDH1A1HSD17B10HTTSMN1; SMN2LMNA | |
| SCHEMBL8869950 | 0.90 | LMNA (0.54) | ALDH1A1HTTSMN1; SMN2LMNACYP3A4 | |
| SCHEMBL8869085 | 0.89 | P4HTM (0.52) | ALDH1A1MAPTKMT2ARAB9AHPGD | |
| SCHEMBL9139277 | 0.88 | ALDH1A1 (0.51) | ALDH1A1HSD17B10HTTSMN1; SMN2LMNA | |
| SCHEMBL7862847 | 0.87 | ALDH1A1 (0.47) | ALDH1A1HSD17B10HTTSMN1; SMN2KMT2A | |
| SCHEMBL8869595 | 0.86 | P4HTM (0.49) | ALDH1A1HSD17B10MAPTCYP2C19KMT2A | |
| SCHEMBL8869015 | 0.86 | P4HTM (0.48) | ALDH1A1SMN1; SMN2MAPTKMT2ARAB9A | |
| SCHEMBL8869449 | 0.86 | P4HTM (0.48) | ALDH1A1HTTMAPTKMT2ARAB9A | |
| SCHEMBL9140397 | 0.85 | ALDH1A1 (0.51) | ALDH1A1HSD17B10HTTSMN1; SMN2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |