Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.45 |
| ▸ | VEGFA | P15692 | 2/20 | 0.45 |
| ▸ | FLT1 | P17948 | 2/20 | 0.45 |
| ▸ | EGLN3 | Q9H6Z9 | 2/20 | 0.45 |
| ▸ | EDNRA | P25101 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.41 |
| ▸ | EDNRB | P24530 | 4/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8868651 | 0.86 | HIF1A (0.46) | EDNRAEDNRBHIF1A | |
| SCHEMBL8870393 | 0.85 | P4HTM (0.49) | EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL8869163 | 0.78 | POLB (0.47) | MEN1KMT2A | |
| SCHEMBL8868423 | 0.76 | ALKBH2 (0.52) | EGLN1VEGFAFLT1EGLN3MEN1 | |
| SCHEMBL9574694 | 0.74 | MEN1 (0.47) | EDNRAMEN1KMT2ASLC22A12EDNRB | |
| SCHEMBL8869499 | 0.73 | AR (0.42) | — | |
| SCHEMBL8869556 | 0.73 | POLB (0.45) | MEN1KMT2A | |
| SCHEMBL8747682 | 0.72 | EDNRA (0.47) | EDNRAEDNRBCASP1 | |
| SCHEMBL8869868 | 0.71 | P4HTM (0.66) | MEN1KMT2A | |
| SCHEMBL8869193 | 0.70 | P4HTM (0.54) | HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |