Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 8/20 | 0.47 |
| ▸ | EDNRB | P24530 | 6/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.44 |
| ▸ | FEN1 | P39748 | 2/20 | 0.44 |
| ▸ | FBP1 | P09467 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.38 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8350452 | 0.76 | EDNRA (0.54) | EDNRAEDNRBALOX5APFEN1FBP1 | |
| SCHEMBL8694517 | 0.74 | EDNRA (0.56) | EDNRAEDNRBFBP1CASP1 | |
| SCHEMBL8868651 | 0.73 | HIF1A (0.46) | EDNRAEDNRBALOX5APFEN1 | |
| SCHEMBL8868209 | 0.72 | EGLN1 (0.45) | EDNRAEDNRBCASP1 | |
| SCHEMBL9574694 | 0.70 | MEN1 (0.47) | EDNRAEDNRBALOX5APFEN1CASP1 | |
| SCHEMBL12335463 | 0.70 | KEAP1 (0.60) | EDNRAEDNRBALOX5APFEN1CASP1 | |
| SCHEMBL12336164 | 0.70 | EDNRA (0.51) | EDNRAEDNRBALOX5APFEN1FBP1 | |
| SCHEMBL4617033 | 0.69 | ALDH1A1 (0.54) | EDNRAEDNRBCASP1 | |
| SCHEMBL10780146 | 0.68 | CASP1 (0.51) | EDNRAEDNRBALOX5APFEN1FBP1 | |
| SCHEMBL10785609 | 0.67 | EDNRA (0.48) | EDNRAEDNRBALOX5APFEN1FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752986-A1 | N-HETEROCYCLYL SULPHONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ZENECA LIMITED (GB) | 1997-01-15 | — | — | EP | claimed |