Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
| ▸ | EDNRA | P25101 | 3/20 | 0.40 |
| ▸ | FEN1 | P39748 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | EDNRB | P24530 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9574709 | 0.84 | FEN1 (0.40) | EDNRAFEN1ALOX5APCASP1EDNRB | |
| SCHEMBL7869169 | 0.84 | GABRA5 (0.44) | — | |
| SCHEMBL8868651 | 0.83 | HIF1A (0.46) | EDNRAFEN1ALOX5APEDNRBNAMPT | |
| SCHEMBL9574909 | 0.78 | HTT (0.44) | MEN1KMT2AHTTALDH1A1LMNA | |
| SCHEMBL7867915 | 0.75 | ALKBH2 (0.40) | FEN1ALOX5AP | |
| SCHEMBL8868209 | 0.74 | EGLN1 (0.45) | MEN1KMT2ASLC22A12EDNRACASP1 | |
| SCHEMBL9574772 | 0.73 | ALDH1A1 (0.41) | MEN1KMT2ATSHRALDH1A1LMNA | |
| SCHEMBL8869198 | 0.73 | POLB (0.47) | MEN1KMT2AEDNRAFEN1ALDH1A1 | |
| SCHEMBL7869455 | 0.71 | P4HTM (0.57) | SMN1; SMN2BCL2L1MCL1 | |
| SCHEMBL8747682 | 0.70 | EDNRA (0.47) | EDNRAFEN1ALOX5APCASP1EDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |