Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | P4HTM | Q9NXG6 | 5/20 | 0.54 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.50 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | BCL2 | P10415 | 1/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8868481 | 0.91 | HDAC3 (0.51) | HDAC3HDAC1HDAC8HDAC4HDAC6 | |
| SCHEMBL8869119 | 0.91 | L3MBTL1 (0.56) | HDAC1P4HTMPRMT1BCL2BCL2L1 | |
| SCHEMBL8869732 | 0.88 | P4HTM (0.53) | P4HTMCA12CA1CA2CA5A | |
| SCHEMBL8870946 | 0.87 | ALDH1A1 (0.55) | P4HTMALDH1A1MEN1KMT2APOLB | |
| SCHEMBL7870480 | 0.86 | SCN3A (0.46) | HDAC3HDAC1HDAC8HDAC4HDAC6 | |
| SCHEMBL8868261 | 0.86 | P4HTM (0.49) | P4HTMCA12CA1CA2CA9 | |
| SCHEMBL8867590 | 0.85 | P4HTM (0.72) | P4HTMKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL9143209 | 0.85 | RAB9A (0.57) | HDAC3HDAC1HDAC8HDAC4HDAC6 | |
| SCHEMBL8868551 | 0.84 | P4HTM (0.47) | P4HTMCA12CA1CA2CA9 | |
| SCHEMBL8869159 | 0.84 | P4HTM (0.58) | HDAC8HDAC6P4HTMNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |