Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.59 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | IL4I1 | Q96RQ9 | 1/20 | 0.37 |
| ▸ | TYMS | P04818 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | S100A4 | P26447 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8870788 | 0.88 | MAOA (0.53) | PBRM1HRH3HSD17B1MAOAMAOB | |
| SCHEMBL8870715 | 0.83 | CASP1 (0.59) | PBRM1CASP1CASP7HSD17B10HRH3 | |
| SCHEMBL5546838 | 0.76 | PBRM1 (0.61) | PBRM1CASP1CASP7HSD17B10BRD4 | |
| SCHEMBL28880 | 0.74 | PBRM1 (1.00) | PBRM1CASP1CASP7HSD17B10HSD17B1 | |
| SCHEMBL354988 | 0.74 | PBRM1 (0.59) | PBRM1CASP1CASP7HSD17B10BRD4 | |
| SCHEMBL27286 | 0.74 | PBRM1 (0.64) | PBRM1CASP1CASP7HSD17B10BRD4 | |
| SCHEMBL1151032 | 0.74 | PBRM1 (0.59) | PBRM1CASP1CASP7HSD17B10BRD4 | |
| SCHEMBL7891254 | 0.74 | PBRM1 (0.59) | PBRM1CASP1CASP7HSD17B10BRD4 | |
| SCHEMBL10138376 | 0.74 | PBRM1 (0.59) | PBRM1CASP1CASP7HSD17B10BRD4 | |
| SCHEMBL31695158 | 0.74 | PBRM1 (0.59) | PBRM1CASP1CASP7HSD17B10BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607928-A | Carbapenem derivatives containing a bicyclic ketone substituent and their use as anti-infectives | ZENECA LIMITED (GB) | 1997-03-04 | — | — | US | disclosed |
| EP-0695753-A1 | Carbapenem derivatives containing a bicyclic substituent, process for their preparation, and their use | ZENECA LIMITED (GB) | 1996-02-07 | — | — | EP | disclosed |