Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 3/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8872220 | 0.72 | LMNA (0.31) | ALDH1A1LMNA | |
| SCHEMBL8872371 | 0.72 | SLC6A2 (0.31) | SLC6A2 | |
| SCHEMBL9198258 | 0.71 | KMT2A (0.31) | SLC6A2KMT2A | |
| SCHEMBL9379716 | 0.68 | CYP19A1 (0.32) | SLC6A2KMT2A | |
| SCHEMBL8872591 | 0.67 | CES2 (0.34) | SLC6A2ALDH1A1MEN1KMT2A | |
| SCHEMBL8860275 | 0.66 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL8871301 | 0.66 | LMNA (0.31) | ALDH1A1LMNA | |
| SCHEMBL26056119 | 0.66 | AOC1 (0.38) | SLC6A2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL8872035 | 0.65 | AOC1 (0.33) | LMNA | |
| SCHEMBL9206194 | 0.62 | SLC6A2 (0.34) | SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5621116-A | CHEMICAL INTERMEDIATES; MEMORY ENHANCERS FOR TREATMENT OF ALZHEIMER*S, ANALGESICS, ANTICONVULSANTS | HOECHST MARION ROUSSEL, INC. (US) | 1997-04-15 | — | — | US | disclosed |
| EP-0415102-B1 | 1,3-Dihydro-1-(pyridinylamino)-2H-indol-2-ones, a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1995-02-01 | — | — | EP | disclosed |
| US-5179119-A | Cognition activators; alzheimer*s disease | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-01-12 | — | — | US | disclosed |
| US-5053511-A | Analgesics; anticonvulsants; treatment for alzheimers disease | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-10-01 | — | — | US | disclosed |
| US-5006537-A | Analgesics, memory enhancement, Alzheimer* disease | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1991-04-09 | — | — | US | disclosed |
| EP-0415102-A1 | 1,3-Dihydro-1-(pyridinylamino)-2H-indol-2-ones, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-03-06 | — | — | EP | disclosed |