Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC1 | P19801 | 2/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.33 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.30 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8860382 | 0.72 | AOC1 (0.33) | AOC1AOC3LMNA | |
| SCHEMBL8872601 | 0.71 | CES2 (0.34) | NAMPTLMNA | |
| SCHEMBL8860275 | 0.70 | ALDH1A1 (0.31) | — | |
| SCHEMBL6847363 | 0.67 | GPR3 (0.37) | AADAT | |
| SCHEMBL8860374 | 0.67 | LMNA (0.38) | AADATLMNA | |
| SCHEMBL9379723 | 0.67 | AOC1 (0.35) | AOC1AOC3 | |
| SCHEMBL8860185 | 0.66 | MEN1 (0.34) | LMNA | |
| SCHEMBL8860363 | 0.65 | ALDH1A1 (0.32) | LMNA | |
| SCHEMBL8872029 | 0.65 | SLC6A2 (0.33) | LMNA | |
| SCHEMBL9380733 | 0.64 | AOC1 (0.32) | AOC1AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5621116-A | CHEMICAL INTERMEDIATES; MEMORY ENHANCERS FOR TREATMENT OF ALZHEIMER*S, ANALGESICS, ANTICONVULSANTS | HOECHST MARION ROUSSEL, INC. (US) | 1997-04-15 | — | — | US | disclosed |
| EP-0415102-B1 | 1,3-Dihydro-1-(pyridinylamino)-2H-indol-2-ones, a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1995-02-01 | — | — | EP | disclosed |
| US-5179119-A | Cognition activators; alzheimer*s disease | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-01-12 | — | — | US | disclosed |
| US-5053511-A | Analgesics; anticonvulsants; treatment for alzheimers disease | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-10-01 | — | — | US | disclosed |
| US-5006537-A | Analgesics, memory enhancement, Alzheimer* disease | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1991-04-09 | — | — | US | disclosed |
| EP-0415102-A1 | 1,3-Dihydro-1-(pyridinylamino)-2H-indol-2-ones, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-03-06 | — | — | EP | disclosed |