Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8873243 | 1.00 | TDP1 (0.41) | TDP1ITGA4ITGB7MAPK1P2RX7 | |
| SCHEMBL8873597 | 0.85 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1SMN1; SMN2HTR2AHTR2C | |
| SCHEMBL8873588 | 0.85 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1SMN1; SMN2HTR2AHTR2C | |
| SCHEMBL8873376 | 0.83 | ITGA4 (0.52) | ITGA4ITGB7P2RX7ALDH1A1L3MBTL1 | |
| SCHEMBL8873387 | 0.83 | ITGA4 (0.52) | ITGA4ITGB7P2RX7ALDH1A1L3MBTL1 | |
| SCHEMBL8874777 | 0.80 | CTSL (0.47) | ITGA4ITGB7P2RX7ALDH1A1L3MBTL1 | |
| SCHEMBL8874785 | 0.80 | CTSL (0.47) | ITGA4ITGB7P2RX7ALDH1A1L3MBTL1 | |
| SCHEMBL17148779 | 0.78 | CASP1 (0.43) | ALDH1A1ATMRAB9ANPC1 | |
| SCHEMBL13077625 | 0.78 | CASP1 (0.43) | ALDH1A1ATMRAB9ANPC1 | |
| SCHEMBL8874701 | 0.76 | AR (0.45) | MAPK1ALDH1A1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610153-A | ENZYME INHIBITORS; TREATMENT OF VASCULAR PROLIFERATION DISORDERS, STERILITY DYSFUNCTION, DYSMENORRHEA | CIBA-GEIGY CORPORATION (US) | 1997-03-11 | — | — | US | disclosed |
| EP-0673371-A1 | BENZAZEPINONE DERIVATIVES | Novartis AG (CH) | 1995-09-27 | — | — | EP | disclosed |
| WO-1994013651-A1 | BENZAZEPINONE DERIVATIVES | CIBA-GEIGY AG (CH) | 1994-06-23 | — | — | WO | disclosed |