Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 7/20 | 0.34 |
| ▸ | FLT3 | P36888 | 4/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 6/20 | 0.34 |
| ▸ | KIT | P10721 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 2/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562815 | 0.83 | KDR (0.49) | GRM4KDRFLT3PDGFRBBRAF | |
| SCHEMBL8875783 | 0.78 | ALDH1A1 (0.36) | GRM4KDRFLT3PDGFRBBRAF | |
| SCHEMBL5523848 | 0.66 | RAF1 (0.52) | KDRFLT3PDGFRBBRAFMAPT | |
| SCHEMBL28217604 | 0.65 | GRM4 (0.44) | GRM4KDRMAPTTP53LMNA | |
| SCHEMBL8567080 | 0.64 | PTPN2 (0.40) | WNT3A | |
| SCHEMBL22476041 | 0.63 | GSK3B (0.52) | BRAFGSK3B | |
| SCHEMBL8562810 | 0.63 | KDR (0.57) | GRM4KDRFLT3PDGFRBBRAF | |
| SCHEMBL58712 | 0.62 | GRM4 (0.46) | GRM4KDRMAPTTP53LMNA | |
| SCHEMBL4246399 | 0.60 | HTR3E (0.49) | GRM4KDRLMNA | |
| SCHEMBL30019653 | 0.59 | HTR3E (0.44) | GRM4KDRMAPTTP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5624937-A | TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |