Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 3/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8877389 | 1.00 | KEAP1 (0.41) | KEAP1MAPK1GAAALDH1A1NPSR1 | |
| SCHEMBL8876593 | 0.98 | KEAP1 (0.39) | KEAP1MAPK1GAAALDH1A1NPSR1 | |
| SCHEMBL8875976 | 0.95 | ALDH1A1 (0.38) | KEAP1MAPK1ALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL8891248 | 0.94 | KEAP1 (0.37) | KEAP1MAPK1GAAALDH1A1NPSR1 | |
| SCHEMBL8883305 | 0.87 | ALDH1A1 (0.36) | MAPK1ALDH1A1NPSR1SMN1; SMN2GRM5 | |
| SCHEMBL8877376 | 0.86 | SIGMAR1 (0.36) | MAPK1GAAALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL8881580 | 0.85 | SIGMAR1 (0.47) | ALDH1A1LMNAMAPTSIGMAR1TSHR | |
| SCHEMBL8877384 | 0.85 | SIGMAR1 (0.47) | MAPK1ALDH1A1NPSR1SMN1; SMN2GRM5 | |
| SCHEMBL8877346 | 0.85 | EPHX2 (0.42) | ALDH1A1NPSR1SMN1; SMN2NPC1LMNA | |
| SCHEMBL8883193 | 0.85 | MAPK1 (0.31) | MAPK1ALDH1A1NPSR1SMN1; SMN2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12233402-B2 | Cross-coupling reaction catalysts, and methods of making and using same | YALE UNIVERSITY (US) | 2025-02-25 | — | — | US | claimed |
| US-20250002519-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | UNIV YALE (US) | 2025-01-02 | — | — | US | claimed |
| US-12071445-B2 | Precatalyst scaffolds for cross-coupling reactions, and methods of making and using same | YALE UNIVERSITY (US) | 2024-08-27 | — | — | US | claimed |
| US-20230203077-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | NATIONAL SCIENCE FOUNDATION | 2023-06-29 | — | — | US | claimed |
| US-11603381-B2 | Precatalyst scaffolds for cross-coupling reactions, and methods of making and using same | YALE UNIVERSITY (US) | 2023-03-14 | — | — | US | claimed |
| US-20210061834-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | NATIONAL SCIENCE FOUNDATION | 2021-03-04 | — | — | US | claimed |
| EP-3736279-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | Yale University (US) | 2020-11-11 | — | — | EP | claimed |
| CN-106795191-B | Novel precatalyst scaffolds for crosslinking reactions and methods of making and using same | 耶鲁大学 | 2020-07-03 | — | — | CN | claimed |
| EP-3204395-B1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | UNIV YALE (US) | 2020-05-27 | — | — | EP | claimed |
| CN-110662753-A | Cross-coupling reaction catalysts and methods of making and using the same | 耶鲁大学 | 2020-01-07 | — | — | CN | claimed |
| US-20170305948-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | UNIV YALE (US) | 2017-10-26 | — | — | US | claimed |
| EP-3204395-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | Yale University (US) | 2017-08-16 | — | — | EP | claimed |
| WO-2016057600-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | YALE UNIVERSITY (US) | 2016-04-14 | — | — | WO | claimed |
| US-12233402-B2 | Cross-coupling reaction catalysts, and methods of making and using same | YALE UNIVERSITY (US) | 2025-02-25 | — | — | US | disclosed |
| US-20250002519-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | UNIV YALE (US) | 2025-01-02 | — | — | US | disclosed |
| US-12071445-B2 | Precatalyst scaffolds for cross-coupling reactions, and methods of making and using same | YALE UNIVERSITY (US) | 2024-08-27 | — | — | US | disclosed |
| EP-2881398-A1 | Method for preparing aminoarylborane compounds or derivatives thereof | Université de Bordeaux I (FR) | 2015-06-10 | — | — | EP | disclosed |
| US-20130253185-A1 | NOVEL CATALYSTS | DALHOUSIE UNIVERSITY (CA) | 2013-09-26 | — | — | US | disclosed |
| US-20130253185-A1 | NOVEL CATALYSTS | DALHOUSIE UNIVERSITY (CA) | 2013-09-26 | — | — | US | disclosed |
| WO-2012068335-A2 | NOVEL CATALYSTS | DALHOUSIE UNIVERSITY (CA) | 2012-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250002519-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | TIMCC, YAP1, TET2 | KEAP1 301/4885MAPK1 4626/4885GAA 3307/4885 |
| US-11603381-B2 | Precatalyst scaffolds for cross-coupling reactions, and methods of making and using same | TIMCC, YAP1, TET2 | KEAP1 363/4885MAPK1 4616/4885GAA 3435/4885 |
| US-20210061834-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | TIMCC, YAP1, TET2 | KEAP1 301/4885MAPK1 4626/4885GAA 3307/4885 |
| US-20230203077-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | TIMCC, YAP1, TET2 | KEAP1 301/4885MAPK1 4626/4885GAA 3307/4885 |
| US-20170305948-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | TIMCC, YAP1, TET2 | KEAP1 301/4885MAPK1 4626/4885GAA 3307/4885 |
| US-12233402-B2 | Cross-coupling reaction catalysts, and methods of making and using same | TET2, TIMCC, MDM4 | KEAP1 557/4885MAPK1 4750/4885GAA 2325/4885 |
| US-12071445-B2 | Precatalyst scaffolds for cross-coupling reactions, and methods of making and using same | TIMCC, YAP1, TET2 | KEAP1 363/4885MAPK1 4616/4885GAA 3435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.