Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8876844 | 0.83 | LMNA (0.43) | LMNAALDH1A1HTR1AADRA1AKDM4E | |
| SCHEMBL8875599 | 0.81 | LMNA (0.45) | LMNAALDH1A1HTR1AADRA1AKDM4E | |
| SCHEMBL8877514 | 0.77 | LMNA (0.45) | LMNAALDH1A1HTR1AADRA1AKDM4E | |
| SCHEMBL8876331 | 0.77 | ALDH1A1 (0.44) | LMNAALDH1A1HTR1AADRA1AKDM4E | |
| SCHEMBL19922703 | 0.73 | PTGS2 (0.53) | HTR1ACYP3A4CYP2D6 | |
| SCHEMBL8875807 | 0.73 | HTR1A (0.66) | LMNAALDH1A1HTR1AADRA1ACYP3A4 | |
| SCHEMBL8876969 | 0.73 | LMNA (0.47) | LMNAALDH1A1HTR1AADRA1AKDM4E | |
| Hydrochloric Acid SCHEMBL8876614 | 0.72 | HTR1A (0.65) | LMNAALDH1A1HTR1AADRA1ACYP3A4 | |
| SCHEMBL8875423 | 0.71 | HTR1A (0.71) | LMNAALDH1A1HTR1AADRA1ACYP3A4 | |
| SCHEMBL8875249 | 0.70 | HTR1A (0.70) | LMNAALDH1A1HTR1AADRA1ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5605896-A | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1997-02-25 | — | — | US | disclosed |
| US-5474994-A | Treating hypertension, urethral and lower urinary tract contractions | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-12-12 | — | — | US | disclosed |
| US-5403842-A | Adrenergic blocking and antiserotonine agents; urogenital disorders including spasms of the urethral tract and prostrate problems | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-04-04 | — | — | US | disclosed |
| WO-1993017007-A1 | HETEROBICYCLIC COMPOUNDS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.P.A. (IT) | 1993-09-02 | — | — | WO | disclosed |
| EP-0558245-A1 | Heterobicyclic compounds as antagogists of alpha-1 adrenergic and SHT1A receptors | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 1993-09-01 | — | — | EP | disclosed |