Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.49 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6092094 | 1.00 | HSD11B1 (0.51) | HSD11B1P2RX7TNFRSF1AALDH1A1HTT | |
| SCHEMBL18317450 | 0.84 | ALDH1A1 (0.45) | P2RX7ALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL18325433 | 0.84 | ALDH1A1 (0.45) | P2RX7ALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL6090902 | 0.84 | CYP1A2 (0.51) | P2RX7ALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL12040547 | 0.84 | GABBR2 (0.53) | P2RX7TNFRSF1AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL6091145 | 0.84 | GABBR2 (0.53) | P2RX7TNFRSF1AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL6090681 | 0.82 | RARB (0.51) | P2RX7ALDH1A1HTTSMN1; SMN2NPSR1 | |
| SCHEMBL6092331 | 0.81 | JUN (0.51) | HSD11B1ALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL8068014 | 0.81 | JUN (0.51) | HSD11B1ALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL6093071 | 0.81 | LMNA (0.47) | ALDH1A1HTTSMN1; SMN2NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |
| US-5506219-A | ANTICHOLESTEROL AND ANTILIPEMIC AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-04-09 | — | — | US | disclosed |
| EP-0444533-A2 | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1991-09-04 | — | — | EP | disclosed |