SCHEMBL887659

SCHEMBL887659

Nc1nc(N)c2c(C#CCCO)n[nH]c2n1

nearest known ligand 0.30

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14833449 0.82 DHFR (0.32)
SCHEMBL887877 0.80 ABL1 (0.31)
SCHEMBL2908006 0.79 TLR7 (0.35) TLR7
SCHEMBL887656 0.78 ABL1 (0.31)
SCHEMBL2909210 0.77 ABL1 (0.33) TLR7
SCHEMBL887869 0.76 MAPT (0.36)
SCHEMBL4582628 0.73 ABL1 (0.32)
SCHEMBL3418187 0.71 TLR7 (0.30) TLR7
SCHEMBL887826 0.67 AHCY (0.38)
SCHEMBL2910181 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 196 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9932643-B2 Detection of methicillin-resistant Staphylococcus aureus ELITECHGROUP B.V. (NL) 2018-04-03 US claimed
US-9677142-B2 Detection of methicillin-resistant Staphylococcus aureus ELITECHGROUP B.V. (NL) 2017-06-13 US claimed
US-9328384-B2 Droplet digital PCR with short minor groove probes ELITECHGROUP B.V. (NL) 2016-05-03 US claimed
US-20150275274-A1 DETECTION OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS ELITECH HOLDING B.V. 2015-10-01 US claimed
EP-2714939-B1 DETECTION OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS ELITECH HOLDING BV (NL) 2015-04-15 EP claimed
EP-1687609-B1 FLUORESCENT PROBES FOR DNA DETECTION BY HYBRIDIZATION WITH IMPROVED SENSITIVITY AND LOW BACKGROUND EPOCH BIOSCIENCES INC (US) 2014-12-10 EP claimed
WO-2013048583-A2 DETECTION OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS ELITECH HOLDING B.V. (NL) 2013-04-04 WO claimed
US-8067177-B2 Amplification methods EPOCH BIOSCIENCES, INC. (US) 2011-11-29 US claimed
US-20110027780-A1 AMPLIFICATION METHODS ELITECHGROUP MDX LLC 2011-02-03 US claimed
US-7790385-B2 Abasic site endonuclease assay ELITECH HOLDING B.V. (NL) 2010-09-07 US claimed
US-7381818-B2 Fluorescent probes containing 5′-minor groove binder, fluorophore and quenching moieties and methods of use thereof EPOCH BIOSCIENCES, INC. (US) 2008-06-03 US claimed
US-7205105-B2 Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis EPOCH BIOSCIENCES, INC. (US) 2007-04-17 US claimed
US-20070048758-A1 IMPROVED PRIMER-BASED AMPLIFICATION METHODS EPOCH BIOSCIENCES, INC. (US) 2007-03-01 US claimed
EP-1687609-A2 FLUORESCENT PROBES FOR DNA DETECTION BY HYBRIDIZATION WITH IMPROVED SENSITIVITY AND LOW BACKGROUND Epoch Biosciences, Inc. (US) 2006-08-09 EP claimed
EP-1468112-A4 REAL-TIME LINEAR DETECTION PROBES: SENSITIVE 5'-MINOR GROOVE BINDER-CONTAINING PROBES FOR PCR ANALYSIS EPOCH BIOSCIENCES INC (US) 2005-11-23 EP claimed
US-20050214797-A1 Fluorescent probes for DNA detection by hybridization with improved sensitivity and low background EPOCH BIOSCIENCES, INC (US) 2005-09-29 US claimed
WO-2005043127-A2 FLUORESCENT PROBES FOR DNA DETECTION BY HYBRIDIZATION WITH IMPROVED SENSITIVITY AND LOW BACKGROUND EPOCH BIOSCIENCES, INC. (US) 2005-05-12 WO claimed
EP-1468112-A2 REAL-TIME LINEAR DETECTION PROBES: SENSITIVE 5'-MINOR GROOVE BINDER-CONTAINING PROBES FOR PCR ANALYSIS Epoch Biosciences, Inc. (US) 2004-10-20 EP claimed
US-20030175728-A1 Real-time linear detection probes: sensitive 5'-minor groove binder-containing probes for PCR analysis EPOCH BIOSCIENCES, INC. (US) 2003-09-18 US claimed
WO-2003062445-A2 REAL-TIME LINEAR DETECTION PROBES: SENSITIVE 5'-MINOR GROOVE BINDER-CONTAINING PROBES FOR PCR ANALYSIS EPOCH BIOSCIENCES, INC. (US) 2003-07-31 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030175728-A1 Real-time linear detection probes: sensitive 5'-minor groove binder-containing probes for PCR analysis RNGTT, DCLRE1B, CNBP TLR7 2768/4885
US-20050214797-A1 Fluorescent probes for DNA detection by hybridization with improved sensitivity and low background SSBP1, DDB1, DNA2 TLR7 1911/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.