SCHEMBL8877458

SCHEMBL8877458

COc1cc(-c2c(F)ccc(F)c2F)c(OC)c2c1N(C)c1ccccc1C2C(=O)O

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.35
MEN1 O00255 3/20 0.34
KMT2A Q03164 3/20 0.34
MAPT P10636 2/20 0.34
TUBB4A P04350 5/20 0.34
TUBB P07437 5/20 0.34
TUBA3C P0DPH7 5/20 0.34
TUBA1B P68363 5/20 0.34
TUBA4A P68366 5/20 0.34
TUBB4B P68371 5/20 0.34
TUBB3 Q13509 5/20 0.34
TUBB2A Q13885 5/20 0.34
TUBB8 Q3ZCM7 5/20 0.34
TUBA3E Q6PEY2 5/20 0.34
TUBA1A Q71U36 5/20 0.34
TUBA1C Q9BQE3 5/20 0.34
TUBB6 Q9BUF5 5/20 0.34
TUBB2B Q9BVA1 5/20 0.34
TUBB1 Q9H4B7 5/20 0.34
ALDH1A1 P00352 5/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7797026 0.79 HDAC4 (0.38) KDM4EMEN1KMT2AMAPTALDH1A1
SCHEMBL7797048 0.79 HDAC4 (0.39) KDM4EMEN1KMT2AMAPTALDH1A1
SCHEMBL7587330 0.74 BRD4 (0.33) MAPTHTTTSHRSMN1; SMN2
SCHEMBL8688713 0.72 KMT2A (0.36) KDM4EMEN1KMT2AMAPTTUBB4A
Acridan SCHEMBL6586926 0.72 ALDH1A1 (0.32) MEN1KMT2AMAPTTUBB4ATUBB
SCHEMBL7787075 0.71 MAPT (0.39) KDM4EMEN1KMT2AMAPTALDH1A1
SCHEMBL7787061 0.69 MAPT (0.37) MEN1KMT2AMAPTALDH1A1HTT
SCHEMBL7796571 0.69 HDAC4 (0.46) MEN1KMT2AMAPTALDH1A1HDAC4
Acridan SCHEMBL7594988 0.69 HDAC3 (0.32) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL8688894 0.68 MEN1 (0.35) MEN1KMT2AMAPTHDAC4HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5670644-A CHEMILUMINESCENT REACTIONS, PEROXIDASE AND PH FOR IMMUNOASSAY LUMIGEN, INC. (US) 1997-09-23 US claimed