Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 6/20 | 0.34 |
| ▸ | LTB4R2 | Q9NPC1 | 6/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | KIF5B | P33176 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL90173 | 0.83 | LMNA (0.39) | LMNAHTTL3MBTL1MAPTHPGD | |
| SCHEMBL89538 | 0.83 | TAAR1 (0.37) | HTTL3MBTL1MAPTHPGDATM | |
| SCHEMBL22215552 | 0.79 | TAAR1 (0.53) | MAPTHPGDTAAR1KDM4EKMT2A | |
| SCHEMBL8282402 | 0.78 | MAPT (0.40) | LMNAHTTL3MBTL1MAPTHPGD | |
| SCHEMBL90030 | 0.78 | PTGES (0.41) | LMNAHTTL3MBTL1MAPTHPGD | |
| SCHEMBL90276 | 0.76 | CNR2 (0.35) | LTB4RLTB4R2KMT2ASCN9A | |
| SCHEMBL29467973 | 0.74 | L3MBTL1 (0.35) | LMNAHTTL3MBTL1HPGDKDM4E | |
| SCHEMBL13434195 | 0.74 | LTB4R (0.41) | LTB4RLTB4R2KDM4EKMT2AUSP2 | |
| SCHEMBL17637579 | 0.73 | L3MBTL1 (0.39) | L3MBTL1MAPTHPGDATMLTB4R | |
| SCHEMBL13955847 | 0.73 | TAAR1 (0.44) | HTTL3MBTL1MAPTHPGDATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129411-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| EP-2420491-A1 | 3 , 5-substitued piperidine compounds as renin inhibitors | Novartis AG (CH) | 2012-02-22 | — | — | EP | disclosed |
| US-20090192148-A1 | Organic Compounds | NOVARTIS AG (CH) | 2009-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192148-A1 | Organic Compounds | REN, ACE, AGTR1 | LMNA 1594/4885HTT 943/4885L3MBTL1 3031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.