Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 8/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | SCN1A | P35498 | 1/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fenpipramide SCHEMBL149504 | 0.84 | CHRM2 (0.60) | CHRM2CHRM1CYP2D6OPRM1HTR1A | |
| SCHEMBL219257 | 0.84 | CHRM2 (0.60) | CHRM2CHRM1CYP2D6OPRM1HTR1A | |
| Fenpipramide SCHEMBL11716116 | 0.84 | OPRM1 (0.56) | CHRM2CHRM1CYP2D6OPRM1HTR1A | |
| Fenpipramide SCHEMBL7558279 | 0.83 | CHRM2 (0.59) | CHRM2CHRM1CYP2D6OPRM1HTR1A | |
| SCHEMBL9670170 | 0.78 | SIGMAR1 (0.55) | CHRM2CHRM1CYP2D6OPRM1HTR1A | |
| SCHEMBL9192560 | 0.75 | CYP2D6 (0.49) | CHRM2CHRM1CYP2D6OPRM1HTR1A | |
| SCHEMBL9190061 | 0.74 | CYP2D6 (0.51) | CHRM2CHRM1CYP2D6OPRM1HTR1A | |
| SCHEMBL6053467 | 0.74 | NPSR1 (0.56) | CHRM2CHRM1CYP2D6OPRM1HTR1A | |
| SCHEMBL11542590 | 0.74 | CYP2D6 (0.50) | CHRM2CHRM1CYP2D6OPRM1HTR1A | |
| Norpipanone SCHEMBL25085 | 0.74 | OPRM1 (0.75) | CHRM2CHRM1CYP2D6OPRM1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607950-A | IRRITABLE BOWEL SYNDROME | PFIZER INC. (US) | 1997-03-04 | — | — | US | disclosed |
| EP-0508988-B1 | MUSCARINIC RECEPTOR ANTAGONISTS | PFIZER LTD (GB) | 1994-03-02 | — | — | EP | disclosed |
| EP-0508988-A1 | MUSCARINIC RECEPTOR ANTAGONISTS. | PFIZER LTD (GB) | 1992-10-21 | — | — | EP | disclosed |
| WO-1991010647-A1 | MUSCARINIC RECEPTOR ANTAGONISTS | PFIZER LIMITED (GB) | 1991-07-25 | — | — | WO | disclosed |
| EP-0235463-A2 | N-substituted-arylalkyl and arylalkylene piperidines as cardiovascular antihistaminic and antisecretory agents | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1987-09-09 | — | — | EP | disclosed |