Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 6/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 6/20 | 0.39 |
| ▸ | TLR3 | O15455 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8884017 | 0.91 | HIF1A (0.41) | HIF1AEPAS1HSD11B1 | |
| SCHEMBL9050508 | 0.87 | HIF1A (0.43) | HIF1AEPAS1HSD11B1SLC6A2SLC6A4 | |
| SCHEMBL8886146 | 0.85 | HIF1A (0.40) | HIF1AEPAS1HSD11B1SLC6A2SLC6A4 | |
| SCHEMBL9051319 | 0.84 | ALDH1A1 (0.47) | HIF1AEPAS1HSD11B1SLC6A2SLC6A4 | |
| SCHEMBL8885347 | 0.84 | HIF1A (0.39) | HIF1AEPAS1HSD11B1SLC6A2SLC6A4 | |
| SCHEMBL8886385 | 0.83 | HIF1A (0.42) | HIF1AEPAS1HRH3HSD11B1MAPT | |
| SCHEMBL8885575 | 0.77 | ALDH1A1 (0.40) | HIF1AEPAS1HSD11B1 | |
| SCHEMBL8886788 | 0.77 | HSD11B1 (0.40) | HSD11B1SLC6A2SLC6A4 | |
| SCHEMBL6936669 | 0.76 | CA2 (0.54) | HIF1AEPAS1TLR3MAOB | |
| SCHEMBL9394843 | 0.74 | KCNE1 (0.40) | HIF1AHSD11B1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690855-B1 | BENZOPYRANES AS POTASSIUM CHANNEL OPENERS | PFIZER LTD (GB) | 1996-12-18 | — | — | EP | disclosed |
| EP-0690855-A1 | BENZOPYRANES AS POTASSIUM CHANNEL OPENERS | PFIZER LTD (GB) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994020491-A1 | BENZOPYRANES AS POTASSIUM CHANNEL OPENERS | PFIZER LIMITED (GB) | 1994-09-15 | — | — | WO | disclosed |