Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8886788 | 0.91 | HSD11B1 (0.40) | HSD11B1SLC6A2SLC6A4ALDH1A1POLB | |
| SCHEMBL9050197 | 0.87 | HIF1A (0.39) | HRH3HMOX1MAOBHSD11B1MAPT | |
| SCHEMBL8883313 | 0.81 | P2RX7 (0.48) | HSD11B1ALDH1A1POLBHTT | |
| SCHEMBL8884017 | 0.77 | HIF1A (0.41) | HSD11B1ALDH1A1POLBHTT | |
| SCHEMBL9394843 | 0.74 | KCNE1 (0.40) | HSD11B1SLC6A2SLC6A4ALDH1A1HTT | |
| SCHEMBL9050508 | 0.73 | HIF1A (0.43) | HSD11B1SLC6A2SLC6A4ALDH1A1HTT | |
| SCHEMBL9050242 | 0.73 | SLC6A2 (0.33) | HRH3MAOBHSD11B1MAPTSLC6A2 | |
| SCHEMBL8885092 | 0.72 | SMN1; SMN2 (0.40) | ALDH1A1 | |
| SCHEMBL9053708 | 0.71 | HSD11B1 (0.39) | HSD11B1ALDH1A1POLB | |
| SCHEMBL8886146 | 0.71 | HIF1A (0.40) | HSD11B1SLC6A2SLC6A4ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690855-B1 | BENZOPYRANES AS POTASSIUM CHANNEL OPENERS | PFIZER LTD (GB) | 1996-12-18 | — | — | EP | disclosed |
| WO-1994020491-A1 | BENZOPYRANES AS POTASSIUM CHANNEL OPENERS | PFIZER LIMITED (GB) | 1994-09-15 | — | — | WO | disclosed |