Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | TMPRSS15 | P98073 | 2/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8885983 | 0.86 | TMPRSS15 (0.46) | GAATMPRSS15TDP1PLAULMNA | |
| SCHEMBL8886607 | 0.79 | ITGB3 (0.57) | TMPRSS15ITGB3ITGA2B | |
| SCHEMBL8410910 | 0.76 | HDAC1 (0.49) | ITGB3ITGA2BHTT | |
| SCHEMBL21339785 | 0.75 | PRSS1 (0.47) | PLAULMNASMN1; SMN2HTTPOLB | |
| SCHEMBL8409042 | 0.74 | LMNA (0.60) | LMNA | |
| SCHEMBL3484826 | 0.73 | GAA (0.59) | GAALMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL599787 | 0.73 | GAA (0.59) | GAALMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL9252896 | 0.73 | MEN1 (0.50) | GAAMEN1KMT2A | |
| SCHEMBL8886144 | 0.73 | ITGB3 (0.54) | TMPRSS15ITGB3ITGA2BPLAU | |
| SCHEMBL8886122 | 0.73 | WDR5 (0.42) | ITGB3ITGA2BALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5597825-A | AGGREGATION INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1997-01-28 | — | — | US | disclosed |
| EP-0496378-B1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | THOMAE GMBH DR K (DE) | 1995-09-20 | — | — | EP | disclosed |
| EP-0496378-A1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |