Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 5/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.45 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | MERTK | Q12866 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 4/20 | 0.43 |
| ▸ | ACHE | P22303 | 4/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8898526 | 0.94 | CYP1A2 (0.50) | CASP6MEN1KMT2AAPPTLR7 | |
| SCHEMBL8889077 | 0.87 | VCP (0.47) | CASP6MEN1KMT2AAPPBCHE | |
| SCHEMBL8898278 | 0.86 | SOS1 (0.52) | CASP6KMT2AAPPTLR7SOS1 | |
| SCHEMBL8907323 | 0.85 | TRIM58 (0.57) | CASP6KMT2ATRIM58RAD52ADRA2A | |
| SCHEMBL8899155 | 0.85 | TRIM58 (0.57) | CASP6KMT2ATRIM58RAD52ADRA2A | |
| SCHEMBL8890083 | 0.84 | POLB (0.55) | CASP6APPSOS1TRIM58BCHE | |
| SCHEMBL8908343 | 0.84 | POLB (0.55) | CASP6APPSOS1TRIM58BCHE | |
| SCHEMBL8901747 | 0.84 | TAAR1 (0.56) | MEN1KMT2AAPPTLR7SOS1 | |
| SCHEMBL8898947 | 0.83 | TLR9 (0.51) | CASP6APPTLR7SOS1TRIM58 | |
| SCHEMBL8889922 | 0.82 | NPY5R (0.49) | APPTLR7SOS1TRIM58RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997020823-A2 | 2-AMINO QUINAZOLINE DERIVATIVES AS NPY RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 1997-06-12 | — | — | WO | claimed |
| WO-1997020823-A2 | 2-AMINO QUINAZOLINE DERIVATIVES AS NPY RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 1997-06-12 | — | — | WO | disclosed |