Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.62 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HNF4A | P41235 | 1/20 | 0.52 |
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL927631 | 0.87 | HDAC4 (0.52) | PDCD1CD274HDAC4HDAC2HDAC8 | |
| SCHEMBL9418403 | 0.86 | GABRA1 (0.56) | PDCD1CD274DPP4ALDH1A1HPGD | |
| SCHEMBL29099761 | 0.83 | DPP4 (0.50) | PDCD1CD274HDAC4HDAC2HDAC8 | |
| SCHEMBL11222694 | 0.83 | PDCD1 (0.48) | PDCD1CD274HDAC4HDAC2HDAC8 | |
| SCHEMBL8858810 | 0.83 | PDCD1 (0.48) | PDCD1CD274HDAC4HDAC2HDAC8 | |
| SCHEMBL10911038 | 0.83 | GABRA1 (0.61) | PDCD1CD274HDAC4HDAC2HDAC8 | |
| SCHEMBL17454820 | 0.83 | PDCD1 (0.48) | PDCD1CD274HDAC4HDAC2HDAC8 | |
| SCHEMBL16429353 | 0.83 | DPP4 (0.67) | PDCD1CD274HDAC4HDAC2HDAC8 | |
| SCHEMBL7204765 | 0.83 | PDCD1 (0.62) | PDCD1CD274HDAC4HDAC2HDAC8 | |
| SCHEMBL8607293 | 0.82 | ELANE (0.54) | PDCD1CD274HDAC4HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10799510-B2 | Derivatives of 6-substituted triazolopyridazines as Rev-Erb agonists | GENFIT (FR) | 2020-10-13 | — | — | US | disclosed |
| US-20170296548-A1 | DERIVATIVES OF 6-SUBSTITUTED TRIAZOLOPYRIDAZINES AS REV-ERB AGONISTS | GENFIT (FR) | 2017-10-19 | — | — | US | disclosed |
| US-9586963-B2 | Derivatives of 6-substituted triazolopyridazines as Rev-Erb agonists | GENFIT (FR) | 2017-03-07 | — | — | US | disclosed |
| US-20150038503-A1 | DERIVATIVES OF 6-SUBSTITUTED TRIAZOLOPYRIDAZINES AS REV-ERB AGONISTS | GENFIT (FR) | 2015-02-05 | — | — | US | disclosed |
| EP-0561637-B1 | A catalyst for asymmetric induction | SUMITOMO CHEMICAL CO (JP) | 1997-02-26 | — | — | EP | disclosed |
| US-5308820-A | Catalyst for asymmetric induction | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1994-05-03 | — | — | US | disclosed |
| EP-0561637-A2 | A catalyst for asymmetric induction | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1993-09-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10799510-B2 | Derivatives of 6-substituted triazolopyridazines as Rev-Erb agonists | NR1D1, NR1D2, PER2 | PDCD1 3642/4885CD274 4573/4885HDAC4 515/4885 |
| US-20170296548-A1 | DERIVATIVES OF 6-SUBSTITUTED TRIAZOLOPYRIDAZINES AS REV-ERB AGONISTS | NR1D1, NR1D2, PER2 | PDCD1 3642/4885CD274 4573/4885HDAC4 515/4885 |
| US-20150038503-A1 | DERIVATIVES OF 6-SUBSTITUTED TRIAZOLOPYRIDAZINES AS REV-ERB AGONISTS | NR1D1, NR1D2, PER2 | PDCD1 3642/4885CD274 4573/4885HDAC4 515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.