Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.37 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.37 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PTPRB | P23467 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CTSA | P10619 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8890927 | 0.94 | ALDH1A1 (0.46) | ALDH1A1POLBLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8891743 | 0.92 | LMNA (0.45) | ALDH1A1POLBLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8892236 | 0.92 | ALDH1A1 (0.40) | ALDH1A1POLBLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8891930 | 0.91 | ALDH1A1 (0.40) | ALDH1A1POLBLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8891419 | 0.88 | ALDH1A1 (0.36) | ALDH1A1POLBLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8891966 | 0.86 | LMNA (0.38) | ALDH1A1POLBLMNAABCC9ABCC8 | |
| SCHEMBL8892248 | 0.85 | ALDH1A1 (0.35) | ALDH1A1POLBLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8892041 | 0.85 | ALDH1A1 (0.48) | ALDH1A1POLBLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8892165 | 0.85 | ABCC9 (0.37) | ALDH1A1LMNAABCC9ABCC8KCNJ11 | |
| SCHEMBL8893258 | 0.84 | ALDH1A1 (0.47) | ALDH1A1POLBLMNAMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607976-A | ANNTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |