Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTPRB | P23467 | 6/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.37 |
| ▸ | CTSA | P10619 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | KCNB1 | Q14721 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8892041 | 0.93 | ALDH1A1 (0.48) | ALDH1A1POLBLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8891578 | 0.92 | ALDH1A1 (0.39) | ALDH1A1POLBLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8891307 | 0.92 | LMNA (0.46) | ALDH1A1POLBLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8893099 | 0.91 | POLB (0.41) | ALDH1A1POLBLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8894257 | 0.87 | ALDH1A1 (0.37) | ALDH1A1POLBLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8892034 | 0.86 | POLB (0.37) | ALDH1A1POLBLMNAPTPRBTBXA2R | |
| SCHEMBL8890927 | 0.85 | ALDH1A1 (0.46) | ALDH1A1POLBLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8891118 | 0.85 | ALDH1A1 (0.36) | ALDH1A1POLBLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8890891 | 0.84 | KEAP1 (0.37) | ALDH1A1LMNAPTPRBTBXA2RKEAP1 | |
| SCHEMBL8891702 | 0.84 | ALDH1A1 (0.48) | ALDH1A1POLBLMNAMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607976-A | ANNTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |