SCHEMBL8891736

SCHEMBL8891736

CC(=O)Nc1ccc(C(=O)O)cc1-n1cc(-c2ccc(Cl)cc2)nc1N

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 2/20 0.46
MAPT P10636 5/20 0.44
MEN1 O00255 5/20 0.44
KMT2A Q03164 5/20 0.44
KDM4E B2RXH2 3/20 0.44
MAPK1 P28482 2/20 0.44
ALDH1A1 P00352 1/20 0.44
HSD17B10 Q99714 1/20 0.41
SMN1; SMN2 Q16637 4/20 0.41
NEU3 Q9UQ49 1/20 0.40
ABL1 P00519 1/20 0.40
CTRC Q99895 3/20 0.40
CDH1 P12830 1/20 0.39
APC P25054 1/20 0.39
CTNNB1 P35222 1/20 0.39
TCF7L2 Q9NQB0 1/20 0.39
NPC1 O15118 2/20 0.39
RAB9A P51151 2/20 0.39
LMNA P02545 1/20 0.39
HDAC1 Q13547 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL8891099 0.94 ADORA3 (0.41) ADORA3MAPTMEN1KMT2AKDM4E
SCHEMBL8891817 0.90 ADORA3 (0.44) ADORA3MAPTMEN1KMT2AKDM4E
SCHEMBL8901022 0.90 ADORA3 (0.44) ADORA3MAPTMEN1KMT2AKDM4E
SCHEMBL8891755 0.89 PTGFR (0.41) ADORA3MAPTMEN1KMT2AKDM4E
Trifluoroacetic Acid SCHEMBL8894608 0.85 ADORA3 (0.40) ADORA3MAPTMEN1KMT2AKDM4E
Trifluoroacetic Acid SCHEMBL8901207 0.85 ALDH1A1 (0.40) ADORA3MAPTMEN1KMT2AKDM4E
SCHEMBL8891105 0.84 ADORA3 (0.39) ADORA3MAPTMEN1KMT2AALDH1A1
SCHEMBL8892669 0.83 SCN2A (0.45) MAPTMEN1KMT2AKDM4EALDH1A1
SCHEMBL8891085 0.82 TLR8 (0.41) ADORA3MAPTNEU3HDAC1
SCHEMBL8892711 0.79 KEAP1 (0.46) MAPTMEN1KMT2AKDM4EMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997033872-A1 ANTI-VIRAL 4-ACYLAMINO-3-[IMIDAZOL-I-YL]-BENZOIC ACID DERIVATIVES BIOTA SCIENTIFIC MANAGEMENT PTY. LTD. (AU) 1997-09-18 WO claimed
WO-1997033872-A1 ANTI-VIRAL 4-ACYLAMINO-3-[IMIDAZOL-I-YL]-BENZOIC ACID DERIVATIVES BIOTA SCIENTIFIC MANAGEMENT PTY. LTD. (AU) 1997-09-18 WO disclosed