SCHEMBL8892669

SCHEMBL8892669

CC(=O)Nc1ccc(C(=O)O)cc1-n1cc(-c2ccc(N3C(=O)c4ccccc4C3=O)cc2)nc1N

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN2A Q99250 2/20 0.45
CA12 O43570 2/20 0.45
CA1 P00915 2/20 0.45
CA2 P00918 2/20 0.45
CA9 Q16790 2/20 0.45
SIRT6 Q8N6T7 1/20 0.43
ALDH1A1 P00352 4/20 0.43
KDM4E B2RXH2 2/20 0.43
GAA P10253 2/20 0.43
MEN1 O00255 4/20 0.42
KMT2A Q03164 4/20 0.42
GFER P55789 1/20 0.42
AHR P35869 1/20 0.41
CA4 P22748 2/20 0.41
CA7 P43166 1/20 0.41
PPARA Q07869 1/20 0.40
HPSE Q9Y251 1/20 0.40
POLB P06746 2/20 0.40
DUSP3 P51452 1/20 0.40
PTPN5 P54829 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8901022 0.87 ADORA3 (0.44) ALDH1A1KDM4EGAAMEN1KMT2A
SCHEMBL8891817 0.85 ADORA3 (0.44) ALDH1A1KDM4EGAAMEN1KMT2A
SCHEMBL8891755 0.83 PTGFR (0.41) ALDH1A1KDM4EGAAMEN1KMT2A
SCHEMBL8891736 0.83 ADORA3 (0.46) ALDH1A1KDM4EMEN1KMT2ARAB9A
Trifluoroacetic Acid SCHEMBL8901207 0.82 ALDH1A1 (0.40) ALDH1A1KDM4EGAAMEN1KMT2A
Trifluoroacetic Acid SCHEMBL8894608 0.80 ADORA3 (0.40) ALDH1A1KDM4EGAAMEN1KMT2A
SCHEMBL8891085 0.78 TLR8 (0.41) MAPT
Trifluoroacetic Acid SCHEMBL8891099 0.78 ADORA3 (0.41) ALDH1A1KDM4EMEN1KMT2APOLB
SCHEMBL8900955 0.76 SCN3A (0.41) ALDH1A1KDM4EGAAMEN1KMT2A
SCHEMBL8892711 0.75 KEAP1 (0.46) ALDH1A1KDM4EGAAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997033872-A1 ANTI-VIRAL 4-ACYLAMINO-3-[IMIDAZOL-I-YL]-BENZOIC ACID DERIVATIVES BIOTA SCIENTIFIC MANAGEMENT PTY. LTD. (AU) 1997-09-18 WO claimed
WO-1997033872-A1 ANTI-VIRAL 4-ACYLAMINO-3-[IMIDAZOL-I-YL]-BENZOIC ACID DERIVATIVES BIOTA SCIENTIFIC MANAGEMENT PTY. LTD. (AU) 1997-09-18 WO disclosed