Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 2/20 | 0.51 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27152573 | 0.83 | CCR5 (0.53) | CCR5KDM4EMAPTTHRBDDB1 | |
| SCHEMBL8893259 | 0.81 | SLC6A9 (0.50) | CCR5SLC6A9KDM4EMAPTTHRB | |
| SCHEMBL27148210 | 0.79 | CCR5 (0.48) | CCR5KDM4EMAPTTHRBDDB1 | |
| SCHEMBL2449593 | 0.76 | CCR5 (0.43) | CCR5KDM4EMAPTTHRBDDB1 | |
| SCHEMBL8892471 | 0.75 | BDKRB2 (0.55) | CCR5OPRM1USP2SMN1; SMN2NPC1L1 | |
| SCHEMBL6088191 | 0.74 | DDB1 (0.44) | CCR5KDM4EMAPTTHRBDDB1 | |
| SCHEMBL4130653 | 0.74 | CCR5 (0.39) | CCR5KDM4EMAPTTHRBDDB1 | |
| SCHEMBL318858 | 0.74 | CCR5 (0.75) | CCR5SLC6A9OPRM1GPR119OPRD1 | |
| SCHEMBL8893501 | 0.74 | BDKRB2 (0.53) | CCR5OPRM1NPC1L1OPRK1 | |
| SCHEMBL31283197 | 0.73 | DDB1 (0.45) | CCR5KDM4EMAPTTHRBDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610142-A | Bradykinin antagonist pseudopeptide derivatives of substituted 4-keto-1,3,8-triazaspiro[4.5]decan-3-alkanoic acids | SCIOS INC. (US) | 1997-03-11 | — | — | US | disclosed |