Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 | P30411 | 3/20 | 0.53 |
| ▸ | NPC1L1 | Q9UHC9 | 8/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.36 |
| ▸ | CCR5 | P51681 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8892471 | 0.89 | BDKRB2 (0.55) | BDKRB2NPC1L1OPRM1OPRK1DDR1 | |
| SCHEMBL8910702 | 0.84 | BDKRB2 (0.52) | BDKRB2NPC1L1OPRL1OPRM1OPRK1 | |
| SCHEMBL8892630 | 0.79 | NPC1L1 (0.67) | BDKRB2NPC1L1OPRL1OPRM1OPRK1 | |
| SCHEMBL8893884 | 0.78 | NPC1L1 (0.56) | BDKRB2NPC1L1OPRL1OPRM1OPRK1 | |
| SCHEMBL8894056 | 0.75 | BDKRB2 (0.59) | BDKRB2NPC1L1 | |
| SCHEMBL21068971 | 0.75 | CYP2D6 (0.50) | MEN1CYP3A4CYP2D6CYP2C9KMT2A | |
| SCHEMBL8893424 | 0.74 | CCR5 (0.51) | NPC1L1OPRM1OPRK1CCR5 | |
| SCHEMBL599707 | 0.73 | NAMPT (0.39) | — | |
| SCHEMBL5134369 | 0.73 | GRIN2B (0.47) | BDKRB2NPC1L1OPRL1OPRM1OPRK1 | |
| SCHEMBL4130653 | 0.72 | CCR5 (0.39) | NPC1L1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610142-A | Bradykinin antagonist pseudopeptide derivatives of substituted 4-keto-1,3,8-triazaspiro[4.5]decan-3-alkanoic acids | SCIOS INC. (US) | 1997-03-11 | — | — | US | disclosed |