Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | IAPP | P10997 | 4/20 | 0.39 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9153692 | 0.93 | ALOX5 (0.47) | GABRA1GABRB2ALOX5PTGS2IAPP | |
| SCHEMBL30810444 | 0.89 | IAPP (0.53) | ALOX5PTGS2IAPPMPOSLC6A4 | |
| SCHEMBL1236262 | 0.89 | IAPP (0.53) | ALOX5PTGS2IAPPMPOSLC6A4 | |
| SCHEMBL8405872 | 0.85 | ALDH1A1 (0.50) | GABRA1GABRB2ALOX5PTGS2IAPP | |
| SCHEMBL15319206 | 0.85 | HSP90AA1 (0.49) | GABRA1GABRB2ALOX5PTGS2POLB | |
| SCHEMBL11109102 | 0.84 | GABRA1 (0.52) | GABRA1GABRB2ALOX5PTGS2IAPP | |
| SCHEMBL29681348 | 0.81 | TDP1 (0.43) | POLBMPOSLC6A4 | |
| SCHEMBL1607140 | 0.81 | TDP1 (0.43) | POLBMPOSLC6A4 | |
| SCHEMBL29681353 | 0.81 | TDP1 (0.43) | POLBMPOSLC6A4 | |
| SCHEMBL9863155 | 0.81 | IAPP (0.50) | IAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691367-A | ANTIINFLAMMATORY AGENTS OR ANTIARTHRITIC AGENTS | ELI LILLY AND COMPANY (US) | 1997-11-25 | — | — | US | disclosed |
| EP-0391644-B1 | Aryl-substituted rhodanine derivatives | LILLY CO ELI (US) | 1996-06-19 | — | — | EP | disclosed |
| US-5356917-A | Antiischemic, antiinflammatory, antiarthritic agents, treat-ment of dystrophic mammals | ELI LILLY AND COMPANY (US) | 1994-10-18 | — | — | US | disclosed |
| US-5158966-A | Aryl-substituted rhodanine derivatives | THE UNIVERSITY OF COLORADO FOUNDATION, INC. (US) | 1992-10-27 | — | — | US | disclosed |
| EP-0500337-A1 | Composition containing aryl-substituted rhodanine derivatives for the treatment of type I diabetes | UNIVERSITY OF COLORADO FOUNDATION, INC. (US) | 1992-08-26 | — | — | EP | disclosed |
| EP-0391644-A2 | Aryl-substituted rhodanine derivatives | ELI LILLY AND COMPANY (US) | 1990-10-10 | — | — | EP | disclosed |