Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | HTR1A | P08908 | 3/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 4/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14355885 | 0.90 | HTR1A (0.68) | DRD2DRD3HTR1ASLC6A2SLC6A4 | |
| SCHEMBL8912798 | 0.87 | DRD2 (0.51) | DRD2DRD3HTR1ASLC6A2SLC6A4 | |
| SCHEMBL7034737 | 0.85 | HTR6 (0.54) | HTR1ASLC6A2SLC6A4SLC6A3ADRA2C | |
| SCHEMBL8902021 | 0.82 | HTR1A (0.52) | DRD2DRD3HTR1ASLC6A2SLC6A4 | |
| SCHEMBL14543394 | 0.79 | ALDH1A1 (0.68) | DRD2DRD3KMT2AHSD17B10MEN1 | |
| SCHEMBL8893443 | 0.77 | DRD2 (0.65) | DRD2DRD3HTR1AADRA2CHSD17B10 | |
| SCHEMBL30306331 | 0.77 | DRD2 (0.52) | DRD2DRD3HTR1ASLC6A2SLC6A4 | |
| SCHEMBL29135260 | 0.77 | DRD2 (0.52) | DRD2DRD3HTR1ASLC6A2SLC6A4 | |
| SCHEMBL15881007 | 0.77 | DRD2 (0.59) | DRD2DRD3HTR1AADRA2CHSD17B10 | |
| SCHEMBL29194060 | 0.76 | MAOB (0.61) | DRD2HTR1AMAPK1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997014689-A1 | ARYL-PIPERAZINE CYCLIC AMINE DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | PIERRE FABRE MEDICAMENT (FR) | 1997-04-24 | — | — | WO | disclosed |