Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | DRD3 | P35462 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 3/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | AGXT | P21549 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.49 |
| ▸ | HTR6 | P50406 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8900904 | 0.87 | DRD2 (0.56) | DRD2DRD3HTR1ASLC6A2SLC6A4 | |
| SCHEMBL14355885 | 0.85 | HTR1A (0.68) | DRD2DRD3HTR1ASLC6A2SLC6A4 | |
| SCHEMBL7034737 | 0.83 | HTR6 (0.54) | HTR1ASLC6A2SLC6A4SLC6A3ADRA2C | |
| SCHEMBL8917679 | 0.80 | MET (0.66) | DRD2DRD3HTR1AHTR6ALDH1A1 | |
| SCHEMBL14543394 | 0.74 | ALDH1A1 (0.68) | DRD2DRD3ALDH1A1GAATSHR | |
| SCHEMBL17659126 | 0.74 | HRH3 (0.59) | HTR1ASLC6A2SLC6A4SLC6A3HTR6 | |
| SCHEMBL30879257 | 0.73 | HRH4 (0.49) | DRD2DRD3ADRA2CHTR6HRH4 | |
| SCHEMBL8347243 | 0.73 | MAOB (0.51) | DRD2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL8893443 | 0.73 | DRD2 (0.65) | DRD2DRD3HTR1AADRA2CALDH1A1 | |
| SCHEMBL3139131 | 0.73 | HTR6 (0.67) | HTR1ASLC6A4AGXTADRA2CHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997014689-A1 | ARYL-PIPERAZINE CYCLIC AMINE DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | PIERRE FABRE MEDICAMENT (FR) | 1997-04-24 | — | — | WO | disclosed |