SCHEMBL8903120

SCHEMBL8903120

C=CCC1CCc2ccc3ccccc3c2C1=O

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 1/20 0.36
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34
MAPK1 P28482 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
HIF1A Q16665 1/20 0.34
NFKB1 P19838 3/20 0.33
NFKB2 Q00653 3/20 0.33
RELA Q04206 3/20 0.33
HTR1A P08908 1/20 0.33
ANPEP P15144 1/20 0.33
DNMT1 P26358 1/20 0.33
CDK4 P11802 1/20 0.32
CCND1 P24385 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8653085 0.86 CYP19A1 (0.41) CYP19A1KDM4EALDH1A1LMNAMAPK1
SCHEMBL9534253 0.74 CYP19A1 (0.55) CYP19A1ALDH1A1CYP1A2CYP2D6CYP2C9
SCHEMBL30286791 0.74 CYP19A1 (0.38) CYP19A1CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL12031024 0.74 CES1 (0.39) CYP19A1KDM4EALDH1A1LMNAMAPK1
SCHEMBL9174741 0.74 CYP19A1 (0.38) CYP19A1CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL8962746 0.71 HTR3A (0.39) CYP19A1CYP1A2CYP2D6
SCHEMBL8516924 0.69 ALDH1A1 (0.40) CYP19A1KDM4EALDH1A1LMNACYP1A2
SCHEMBL23801871 0.69 CYP3A4 (0.41) CYP1A2CYP2D6
SCHEMBL3100368 0.66 HTR1A (0.55) HTR1A
SCHEMBL12050098 0.66 CYP1A2 (0.36) CYP1A2CYP2D6CYP2C9CYP2C19HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5674387-A USEFUL FOR SEPARATION OF UNDERIVATIZED ENANTIOMERS OF NONSTEROIDAL ANTIINFLAMMATORY AGENTS RESEARCH CORPORATION TECHNOLOGIES, INC. (US) 1997-10-07 US disclosed
US-5484530-A CARBOXYLIC ACIDS AND ENANTIOMORPHS RESEARCH CORPORATION TECHNOLOGIES, INC. (US) 1996-01-16 US disclosed
US-5387338-A An optical isomer separators RESEARCH CORPORATION TECHNOLOGIES, INC. (US) 1995-02-07 US disclosed
US-5256293-A Immobilizing enantiomer on support effective for use in chromatographic separation RESEARCH CORPORATION TECHNOLOGIES, INC. (US) 1993-10-26 US disclosed
WO-1993006080-A1 SEPARATION OF ENANTIOMERS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND CHIRAL SELECTOR THEREFOR RESEARCH CORPORATION TECHNOLOGIES, INC. (US) 1993-04-01 WO disclosed