Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.36 |
| ▸ | RELA | Q04206 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20113277 | 0.83 | CYP19A1 (0.43) | CES1CYP19A1ANPEPDNMT1ALDH1A1 | |
| SCHEMBL9174741 | 0.81 | CYP19A1 (0.38) | CYP19A1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL30286791 | 0.81 | CYP19A1 (0.38) | CYP19A1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9095769 | 0.74 | KDM4E (0.41) | CYP19A1CYP1A2CYP2C9CYP2C19ANPEP | |
| SCHEMBL8903120 | 0.74 | CYP19A1 (0.36) | CYP19A1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10080460 | 0.72 | CYP1A2 (0.33) | CYP19A1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL30617063 | 0.72 | DNMT1 (0.44) | CES1CYP1A2CYP2C9CYP2C19ANPEP | |
| SCHEMBL6759607 | 0.72 | DNMT1 (0.44) | CES1CYP1A2CYP2C9CYP2C19ANPEP | |
| SCHEMBL23850520 | 0.70 | ALDH1A1 (0.35) | CES1ALDH1A1MAPTTHRBSMN1; SMN2 | |
| SCHEMBL1825039 | 0.70 | ACHE (0.49) | CES1CYP19A1ANPEPDNMT1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426613-B2 | Synthesis of substituted tetrahydroindenyl complexes | TOTAL PETROCHEMICALS RESEARCH FELUY (BE) | 2013-04-23 | — | — | US | disclosed |
| US-8426613-B2 | Synthesis of substituted tetrahydroindenyl complexes | TOTAL PETROCHEMICALS RESEARCH FELUY (BE) | 2013-04-23 | — | — | US | disclosed |
| US-20110306741-A1 | SYNTHESIS OF SUBSTITUTED TETRAHYDROINDENYL COMPLEXES | GOSUDARSTVENNOE UCHEBNO-NAUCHNOE UCHREZHDENIE KHIMICHESKY FAKULTET MOSKOVSKOGO | 2011-12-15 | — | — | US | disclosed |
| US-20110306741-A1 | SYNTHESIS OF SUBSTITUTED TETRAHYDROINDENYL COMPLEXES | GOSUDARSTVENNOE UCHEBNO-NAUCHNOE UCHREZHDENIE KHIMICHESKY FAKULTET MOSKOVSKOGO | 2011-12-15 | — | — | US | disclosed |
| WO-2010076188-A1 | SYNTHESIS OF SUBSTITUTED TETRAHYDROINDENYL COMPLEXES | TOTAL PETROCHEMICALS RESEARCH FELUY (BE) | 2010-07-08 | — | — | WO | disclosed |
| WO-2010077163-A1 | SYNTHESIS OF SUBSTITUTED TETRAHYDROINDENYL COMPLEXES, METALLOCENES PRODUCED THEREFROM AND USE OF THE METALLOCENES IN POLYMERISATION PROCESSES | GOSUDARSTVENNOE UCHEBNO-NAUCHNOE UCHREZHDENIE KHIMICHESKY FAKULTET MOSKOVSKOGO GOSUDARSTVENNOGO UNIVERSITETA IM. M.V.LOMONOSOVA (RU) | 2010-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306741-A1 | SYNTHESIS OF SUBSTITUTED TETRAHYDROINDENYL COMPLEXES | COASY, TPR, PIN1 | CES1 4137/4885CYP19A1 1136/4885CYP1A2 174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.