SCHEMBL8903151

SCHEMBL8903151

O=C(c1ccc(I)cc1)c1ccc(O)c(Cl)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B1 P14061 4/20 0.54
HSD17B2 P37059 4/20 0.54
SRD5A2 P31213 1/20 0.50
HSP90AA1 P07900 1/20 0.47
HSP90AB1 P08238 1/20 0.47
MAPK1 P28482 1/20 0.42
SIRT1 Q96EB6 1/20 0.42
TPMT P51580 1/20 0.42
TSHR P16473 1/20 0.42
HSD17B10 Q99714 1/20 0.42
HTT P42858 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
SLC22A6 Q4U2R8 1/20 0.42
SLC22A8 Q8TCC7 1/20 0.42
CNR1 P21554 1/20 0.41
CNR2 P34972 1/20 0.41
CA2 P00918 2/20 0.41
CA1 P00915 1/20 0.41
LMNA P02545 2/20 0.40
ESR1 P03372 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1758305 0.88 HSD17B1 (0.59) HSD17B1HSD17B2SRD5A2HSP90AA1HSP90AB1
SCHEMBL1758320 0.85 HSD17B1 (0.61) HSD17B1HSD17B2SRD5A2HSP90AA1HSP90AB1
SCHEMBL8050245 0.83 HSD17B1 (0.64) HSD17B1HSD17B2SRD5A2HSP90AA1HSP90AB1
SCHEMBL6744685 0.82 SIRT1 (0.59) SIRT1TPMTHTTSMN1; SMN2SLC22A6
SCHEMBL3468297 0.81 HSD17B1 (0.54) HSD17B1HSD17B2SRD5A2HSP90AA1HSP90AB1
SCHEMBL9389844 0.77 TPMT (0.65) SRD5A2MAPK1TPMTHTTSMN1; SMN2
SCHEMBL1244094 0.77 TPMT (0.65) SRD5A2MAPK1TPMTHTTSMN1; SMN2
SCHEMBL3841301 0.77 TPMT (0.65) SRD5A2MAPK1TPMTHTTSMN1; SMN2
SCHEMBL10352926 0.76 HSD17B1 (0.79) HSD17B1HSD17B2HSP90AA1HSP90AB1CA2
SCHEMBL11269211 0.76 ALDH1A1 (0.58) HSD17B1HSD17B2SRD5A2MAPK1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5637771-A Compound useful for lowering cholesterol HOFFMANN-LA ROCHE INC. (US) 1997-06-10 US disclosed
US-5574071-A ADMINISTERING PHENYLALKYLAMINO KETONES HOFFMANN-LA ROCHE INC. (US) 1996-11-12 US disclosed
US-5495048-A ANTICHOLESTEROL AGENTS HOFFMANN-LA ROCHE INC. (US) 1996-02-27 US disclosed