Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 2/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8905725 | 0.90 | AKR1B1 (0.38) | NPC1RAB9ASRD5A2PDE2A | |
| SCHEMBL8905805 | 0.87 | LMNA (0.38) | NPC1RAB9AKMT2ASRD5A2HPGD | |
| SCHEMBL8905900 | 0.86 | LMNA (0.37) | NPC1KMT2ASRD5A2HPGDSMN1; SMN2 | |
| SCHEMBL8904194 | 0.86 | CCNA2 (0.38) | RAB9AKMT2AHPGDALDH1A1LMNA | |
| SCHEMBL8905938 | 0.86 | MEN1 (0.38) | NPC1KMT2AHPGDSMN1; SMN2PKM | |
| SCHEMBL8906156 | 0.86 | ALDH1A1 (0.35) | NPC1RAB9AKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL8904850 | 0.85 | ALDH1A1 (0.40) | KMT2AHPGDSMN1; SMN2GAAALDH1A1 | |
| SCHEMBL9030270 | 0.85 | PDE3B (0.42) | NPC1RAB9AKMT2AHPGDALDH1A1 | |
| SCHEMBL8904626 | 0.84 | CYP1A2 (0.48) | KMT2AHPGDMEN1 | |
| SCHEMBL8904827 | 0.84 | PDE3B (0.36) | NPC1RAB9AKMT2AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5622948-A | ANALGESICS | SYNTEX (U.S.A.) INC. (US) | 1997-04-22 | — | — | US | disclosed |
| EP-0714895-A1 | Pyrrole derivatives | F. Hoffmann-La Roche AG (CH) | 1996-06-05 | — | — | EP | disclosed |