Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
| ▸ | TYMP | P19971 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8906156 | 0.90 | ALDH1A1 (0.35) | LMNAPOLBSMN1; SMN2KMT2AHPGD | |
| SCHEMBL8905805 | 0.89 | LMNA (0.38) | LMNAPOLBAKR1B1CYP2C19SMN1; SMN2 | |
| SCHEMBL8905938 | 0.88 | MEN1 (0.38) | LMNAAKR1B1SMN1; SMN2CYP1A2KMT2A | |
| SCHEMBL8904194 | 0.88 | CCNA2 (0.38) | LMNAAKR1B1CYP1A2KMT2AHPGD | |
| SCHEMBL8904850 | 0.88 | ALDH1A1 (0.40) | LMNAPOLBAKR1B1SMN1; SMN2CYP1A2 | |
| SCHEMBL9030270 | 0.88 | PDE3B (0.42) | LMNACYP1A2KMT2AHPGDHTT | |
| SCHEMBL8905531 | 0.86 | CYP3A4 (0.43) | LMNAPOLBAKR1B1CYP2C19SMN1; SMN2 | |
| SCHEMBL8904574 | 0.86 | NPC1 (0.42) | LMNAPOLBSMN1; SMN2KMT2AHPGD | |
| SCHEMBL8904626 | 0.86 | CYP1A2 (0.48) | CYP1A2KMT2AHPGDCYP2C9MEN1 | |
| SCHEMBL8904827 | 0.86 | PDE3B (0.36) | LMNACYP2C19SMN1; SMN2CYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5622948-A | ANALGESICS | SYNTEX (U.S.A.) INC. (US) | 1997-04-22 | — | — | US | disclosed |
| EP-0714895-A1 | Pyrrole derivatives | F. Hoffmann-La Roche AG (CH) | 1996-06-05 | — | — | EP | disclosed |