Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 5/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8906156 | 0.89 | ALDH1A1 (0.35) | LMNAMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL8904194 | 0.89 | CCNA2 (0.38) | LMNAMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL8905900 | 0.89 | LMNA (0.37) | LMNAMEN1KMT2AHPGDCYP2C9 | |
| SCHEMBL8905938 | 0.89 | MEN1 (0.38) | LMNAMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL9030270 | 0.89 | PDE3B (0.42) | LMNAMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL8904850 | 0.89 | ALDH1A1 (0.40) | LMNAMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL8904574 | 0.87 | NPC1 (0.42) | LMNAMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL8904827 | 0.87 | PDE3B (0.36) | LMNAMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL8905998 | 0.87 | ALDH1A1 (0.41) | LMNAMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL8904626 | 0.87 | CYP1A2 (0.48) | MEN1KMT2AHPGDCYP2C9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5622948-A | ANALGESICS | SYNTEX (U.S.A.) INC. (US) | 1997-04-22 | — | — | US | disclosed |
| EP-0714895-A1 | Pyrrole derivatives | F. Hoffmann-La Roche AG (CH) | 1996-06-05 | — | — | EP | disclosed |