SCHEMBL8908232

SCHEMBL8908232

Cc1nc(Cl)nc(Nc2ccccc2)n1

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFKB1 P19838 3/20 0.75
MAPT P10636 3/20 0.75
MEN1 O00255 2/20 0.75
KMT2A Q03164 2/20 0.75
MAPK1 P28482 1/20 0.75
LMNA P02545 1/20 0.69
NPC1 O15118 2/20 0.63
RAB9A P51151 1/20 0.63
CA12 O43570 1/20 0.54
CA1 P00915 1/20 0.54
CA2 P00918 1/20 0.54
CA9 Q16790 1/20 0.54
SMN1; SMN2 Q16637 2/20 0.50
JAK2 O60674 1/20 0.49
LRRK2 Q5S007 1/20 0.49
KCNH3 Q9ULD8 2/20 0.49
ALDH1A1 P00352 1/20 0.49
KDM4E B2RXH2 1/20 0.48
GAA P10253 1/20 0.48
APP P05067 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11936604 0.86 MAPT (0.63) NFKB1MAPTMEN1KMT2AMAPK1
SCHEMBL21655135 0.86 NFKB1 (1.00) NFKB1MAPTMEN1KMT2AMAPK1
SCHEMBL113103 0.86 NFKB1 (1.00) NFKB1MAPTMEN1KMT2AMAPK1
SCHEMBL1923883 0.86 MAPT (1.00) NFKB1MAPTMEN1KMT2AMAPK1
SCHEMBL115405 0.86 MAPT (0.57) NFKB1MAPTMEN1KMT2AMAPK1
SCHEMBL4572354 0.85 NPC1 (0.66) NFKB1MAPTMEN1KMT2AMAPK1
SCHEMBL14511079 0.83 NFKB1 (0.84) NFKB1MAPTMEN1KMT2AMAPK1
SCHEMBL23643402 0.82 NFKB1 (0.92) NFKB1MAPTMEN1KMT2AMAPK1
SCHEMBL14511076 0.82 NFKB1 (0.54) NFKB1MAPTMEN1KMT2AMAPK1
SCHEMBL11885185 0.81 LMNA (1.00) NFKB1MAPTMEN1KMT2AMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8188273-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES, LLC. (US) 2012-05-29 US disclosed
US-20120040837-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2012-02-16 US disclosed
US-8067588-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES LLC (US) 2011-11-29 US disclosed
US-20090093481-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2009-04-09 US disclosed
US-20090041938-A1 MIXTURES OF FIBRE REACTIVE DYES PRODUCTION AND USE THEREOF DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2009-02-12 US disclosed
US-20090041938-A1 MIXTURES OF FIBRE REACTIVE DYES PRODUCTION AND USE THEREOF DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2009-02-12 US disclosed
US-7468081-B2 Mono-, di-or trichromatic dyeing or printing of natural or synthetic polyamide fiber materials DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2008-12-23 US disclosed
US-7468081-B2 Mono-, di-or trichromatic dyeing or printing of natural or synthetic polyamide fiber materials DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2008-12-23 US disclosed
US-7381228-B2 Mono-, Di- or Trichromatic Dyeing or Printing of Natural or Synthetic Polyamide Fiber Materials DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2008-06-03 US disclosed
US-7381228-B2 Mono-, Di- or Trichromatic Dyeing or Printing of Natural or Synthetic Polyamide Fiber Materials DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2008-06-03 US disclosed
US-20070199162-A1 Mono-, Di- or Trichromatic Dyeing or Printing of Natural or Synthetic Polyamide Fiber Materials DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2007-08-30 US disclosed
US-20070199162-A1 Mono-, Di- or Trichromatic Dyeing or Printing of Natural or Synthetic Polyamide Fiber Materials DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2007-08-30 US disclosed
US-20070199163-A1 Mono-, Di- or Trichromatic Dyeing or Printing of Natural or Synthetic Polyamide Fiber Materials DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2007-08-30 US disclosed
US-20070199163-A1 Mono-, Di- or Trichromatic Dyeing or Printing of Natural or Synthetic Polyamide Fiber Materials DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2007-08-30 US disclosed
US-20070113356-A1 Reactive polysaccharide derivatives, their preparation and their use CIBA SPECIALTY CHEMICALS CORP. (US) 2007-05-24 US disclosed
US-20070113356-A1 Reactive polysaccharide derivatives, their preparation and their use CIBA SPECIALTY CHEMICALS CORP. (US) 2007-05-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070113356-A1 Reactive polysaccharide derivatives, their preparation and their use C1S, H1-0, H1-4 NFKB1 1619/4885MAPT 4550/4885MEN1 1738/4885
US-20090093481-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES HELZ, API5, CRYZ NFKB1 2863/4885MAPT 2948/4885MEN1 3633/4885
US-20120040837-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES HELZ, API5, CRYZ NFKB1 2863/4885MAPT 2948/4885MEN1 3633/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.