Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.55 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.54 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.54 |
| ▸ | RARG | P13631 | 10/20 | 0.50 |
| ▸ | RARA | P10276 | 1/20 | 0.50 |
| ▸ | RARB | P10826 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8907967 | 0.85 | CYP26A1 (0.56) | CYP3A4CYP26A1CYP26B1RARGRARA | |
| SCHEMBL8907584 | 0.84 | CYP3A4 (0.61) | CYP3A4CYP26A1CYP26B1PPARGNPC1 | |
| SCHEMBL8907955 | 0.79 | RARG (0.42) | CYP3A4CYP26A1CYP26B1RARGRARA | |
| SCHEMBL9270229 | 0.77 | RARG (0.62) | CYP3A4CYP26A1CYP26B1RARGRARA | |
| SCHEMBL8907954 | 0.77 | RARG (0.44) | CYP3A4CYP26A1CYP26B1RARGRARA | |
| SCHEMBL8907772 | 0.76 | PARP15 (0.50) | PPARGNPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL8907597 | 0.73 | MAOB (0.49) | CYP3A4CYP26A1CYP26B1RARBNPC1 | |
| SCHEMBL5419894 | 0.73 | CYP3A4 (0.62) | CYP3A4CYP26A1CYP26B1RARGRARA | |
| SCHEMBL8907762 | 0.73 | L3MBTL1 (0.49) | CYP3A4CYP26A1CYP26B1NPC1MAPT | |
| SCHEMBL8908796 | 0.73 | CYP3A4 (0.75) | CYP3A4CYP26A1CYP26B1RARGRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5654331-A | SKIN AND RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; ANTIALLERGENS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) | 1997-08-05 | — | — | US | disclosed |
| US-5476860-A | Diaromatic compounds derived from a salicylic unit and their use in human and veterinary medicine and in cosmetics | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD GALDERMA) (FR) | 1995-12-19 | — | — | US | disclosed |