Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.31 |
| ▸ | CDC25A | P30304 | 2/20 | 0.31 |
| ▸ | CDC25B | P30305 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GMNN | O75496 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8907599 | 0.85 | CYP1A2 (0.38) | TSHRALDH1A1CYP1A2LMNAPOLB | |
| SCHEMBL8908354 | 0.81 | ALDH1A1 (0.31) | ALDH1A1HTT | |
| SCHEMBL11481881 | 0.76 | CDC25B (0.41) | TSHRMAP2K7CDC25ACDC25BALDH1A1 | |
| SCHEMBL8908939 | 0.75 | POLB (0.47) | ALDH1A1CYP1A2LMNAPOLBMAPT | |
| SCHEMBL8907689 | 0.68 | SERPINE1 (0.36) | ALDH1A1POLBMAPTKDM4ETP53 | |
| SCHEMBL8907884 | 0.68 | S100A4 (0.36) | TSHRALDH1A1POLBKDM4EHPGD | |
| SCHEMBL8908307 | 0.67 | ACP3 (0.40) | ALDH1A1POLBKDM4ERAB9A | |
| SCHEMBL8908407 | 0.62 | ALDH1A1 (0.39) | TSHRALDH1A1CYP1A2LMNAPOLB | |
| SCHEMBL4322292 | 0.62 | TSHR (0.48) | TSHRMAP2K7CDC25ACDC25BALDH1A1 | |
| SCHEMBL8908590 | 0.62 | TSHR (0.36) | TSHRALDH1A1POLBMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682657-B1 | 9H-INDENO[1,2-b]PYRAZINE-3(4H)-ONES AND 9H-INDENO[1,2-b]PYRAZINE-2,3(1H,4H)-DIONES AND THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1997-11-19 | — | — | EP | claimed |