Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | MITF | O75030 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8907599 | 0.67 | CYP1A2 (0.38) | TSHRALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL8907689 | 0.65 | SERPINE1 (0.36) | ALDH1A1MAPTKMT2AMEN1KDM4E | |
| SCHEMBL8907884 | 0.65 | S100A4 (0.36) | TSHRALDH1A1HPGDKDM4EPOLB | |
| SCHEMBL8909107 | 0.62 | TSHR (0.33) | TSHRALDH1A1HPGDALOX12MAPT | |
| SCHEMBL8908307 | 0.61 | ACP3 (0.40) | ALDH1A1KDM4EPOLBRAB9AAPAF1 | |
| SCHEMBL1107119 | 0.61 | ACHE (0.47) | ALDH1A1MAPTKMT2AMEN1CHRM2 | |
| SCHEMBL10880774 | 0.60 | TBXA2R (0.40) | — | |
| SCHEMBL2763720 | 0.59 | SERPINE1 (0.35) | ALDH1A1HPGDKMT2AMEN1KDM4E | |
| SCHEMBL8908407 | 0.59 | ALDH1A1 (0.39) | TSHRALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL11647247 | 0.57 | PARP3 (0.42) | ALDH1A1HPGDALOX12KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682657-B1 | 9H-INDENO[1,2-b]PYRAZINE-3(4H)-ONES AND 9H-INDENO[1,2-b]PYRAZINE-2,3(1H,4H)-DIONES AND THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1997-11-19 | — | — | EP | claimed |
| US-5646146-A | CENTRAL NERVOUS SYSTEM DISORDERS | NOVO NORDISK A/S (DK) | 1997-07-08 | — | — | US | claimed |