Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 8/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8908817 | 0.71 | REN (0.38) | REN | |
| SCHEMBL8908823 | 0.67 | REN (0.34) | REN | |
| Hydrochloric Acid SCHEMBL9800528 | 0.65 | REN (0.52) | REN | |
| SCHEMBL9800601 | 0.64 | REN (0.48) | RENALDH1A1 | |
| SCHEMBL8910252 | 0.63 | KDM4E (0.39) | RENMEN1KMT2ANPSR1ALDH1A1 | |
| SCHEMBL9800540 | 0.63 | REN (0.49) | REN | |
| SCHEMBL8910133 | 0.63 | REN (0.51) | REN | |
| SCHEMBL9800598 | 0.62 | REN (0.48) | REN | |
| SCHEMBL7328969 | 0.62 | REN (0.52) | REN | |
| SCHEMBL8910205 | 0.62 | GPR132 (0.36) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688946-A | DIPEPTIDES FOR HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS | HOFFMANN LA ROCHE INC. (US) | 1997-11-18 | — | — | US | disclosed |