SCHEMBL8910205

SCHEMBL8910205

NC(=O)C(Cc1cccnc1)OC(=O)N(C(Cc1c[nH]cn1)C(N)=O)[C@@H](CC1CCCCC1)[C@@H](O)[C@@H](O)C1CC1

nearest known ligand 0.36

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR132 Q9UNW8 1/20 0.36
REN P00797 19/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8908817 0.87 REN (0.38) REN
SCHEMBL8909618 0.82 SIRT2 (0.37) GPR132REN
SCHEMBL8909690 0.76 REN (0.36) REN
SCHEMBL8910700 0.75 REN (0.40) REN
SCHEMBL8909154 0.72 REN (0.41) REN
SCHEMBL8910563 0.71 REN (0.41) REN
SCHEMBL8909458 0.71 PYGL (0.36) REN
SCHEMBL8910252 0.71 KDM4E (0.39) REN
SCHEMBL8908823 0.71 REN (0.34) REN
SCHEMBL9641474 0.70 OPRM1 (0.36) REN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5688946-A DIPEPTIDES FOR HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS HOFFMANN LA ROCHE INC. (US) 1997-11-18 US disclosed