Sugi Predict

Sugi Predict / Compounds / SCHEMBL8909899

SCHEMBL8909899

SCHEMBL8909899

FC(F)(F)Oc1ccc(/C=N/Nc2nc(NCCN3CCOCC3)nc(Nc3ccc(OC(F)(F)F)cc3)n2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ABL1 P00519 5/20 0.56
▸ BCR P11274 5/20 0.56
▸ MEN1 O00255 3/20 0.53
▸ KMT2A Q03164 3/20 0.53
▸ MAPT P10636 3/20 0.52
▸ HPGD P15428 2/20 0.52
▸ BACE1 P56817 1/20 0.50
▸ EGFR P00533 1/20 0.50
▸ ALDH1A1 P00352 3/20 0.49
▸ HTT P42858 2/20 0.49
▸ KDM4E B2RXH2 2/20 0.49
▸ LMNA P02545 2/20 0.49
▸ CYP3A4 P08684 1/20 0.49
▸ CYP2D6 P10635 1/20 0.49
▸ CYP2C9 P11712 1/20 0.49
▸ RAB9A P51151 1/20 0.49
▸ GAA P10253 2/20 0.46
▸ MAPK1 P28482 1/20 0.46
▸ SMN1; SMN2 Q16637 1/20 0.46
▸ DDX3X O00571 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8910058 0.90 MEN1 (0.48) ABL1BCRMEN1KMT2AMAPT
SCHEMBL8909361 0.84 CTSS (0.63) MEN1KMT2AMAPTALDH1A1HTT
SCHEMBL414897 0.82 ABL1 (0.41) ABL1BCRMEN1KMT2AMAPT
SCHEMBL414896 0.82 ABL1 (0.41) ABL1BCRMEN1KMT2AMAPT
SCHEMBL10241398 0.82 ABL1 (0.41) ABL1BCRMEN1KMT2AMAPT
SCHEMBL8909203 0.80 MAPT (0.53) MEN1KMT2AMAPTHPGDALDH1A1
SCHEMBL13883261 0.80 CTSS (0.60) MEN1KMT2AMAPTALDH1A1HTT
SCHEMBL8908761 0.80 MAPT (0.63) MEN1KMT2AMAPTHPGDALDH1A1
SCHEMBL608154 0.80 CTSS (0.58) MEN1KMT2AMAPTALDH1A1HTT
SCHEMBL608153 0.80 CTSS (0.58) MEN1KMT2AMAPTALDH1A1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8188273-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES, LLC. (US) 2012-05-29 — — US disclosed
US-8188273-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES, LLC. (US) 2012-05-29 — — US disclosed
US-20120040837-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2012-02-16 — — US disclosed
US-20120040837-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2012-02-16 — — US disclosed
US-8067588-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES LLC (US) 2011-11-29 — — US disclosed
US-8067588-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES LLC (US) 2011-11-29 — — US disclosed
US-20090093481-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2009-04-09 — — US disclosed
US-20090093481-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2009-04-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090093481-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES HELZ, API5, CRYZ ABL1 3985/4885BCR 4570/4885MEN1 3633/4885
US-20120040837-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES HELZ, API5, CRYZ ABL1 3985/4885BCR 4570/4885MEN1 3633/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.