Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30571321 | 1.00 | CYP19A1 (0.39) | CYP19A1PRKCZMAPTKDM4ELMNA | |
| SCHEMBL29559681 | 1.00 | CYP19A1 (0.39) | CYP19A1PRKCZMAPTKDM4ELMNA | |
| SCHEMBL14856279 | 0.88 | PRKCZ (0.46) | CYP19A1PRKCZMAPTKDM4ELMNA | |
| SCHEMBL152013 | 0.87 | CYP19A1 (0.45) | CYP19A1PRKCZMAPTKDM4ELMNA | |
| Isoquinoline SCHEMBL7848297 | 0.87 | TNF (0.44) | CYP19A1PRKCZMAPTKDM4ELMNA | |
| Isoquinoline SCHEMBL8132700 | 0.87 | TNF (0.44) | CYP19A1PRKCZMAPTKDM4ELMNA | |
| SCHEMBL31613470 | 0.84 | PRKCZ (0.48) | CYP19A1PRKCZMAPTKDM4ELMNA | |
| SCHEMBL140144 | 0.84 | PRKCZ (0.48) | CYP19A1PRKCZMAPTKDM4ELMNA | |
| Hydrochloric Acid SCHEMBL38666248 | 0.84 | CYP19A1 (0.43) | CYP19A1PRKCZMAPTKDM4ELMNA | |
| Bromide SCHEMBL30097072 | 0.84 | CYP19A1 (0.43) | CYP19A1PRKCZMAPTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 265 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4499638-A1 | PYRIDO-[3,4-D]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 DERIVATIVES | Ventus Therapeutics U.S., Inc. (US) | 2025-02-05 | — | — | EP | claimed |
| US-11786600-B2 | Cliptac composition | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2023-10-17 | — | — | US | claimed |
| WO-2023183943-A1 | PYRIDO-[3,4-D]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 DERIVATIVES | VENTUS THERAPEUTICS U.S., INC. (US) | 2023-09-28 | — | — | WO | claimed |
| US-20190275161-A1 | CLIPTAC COMPOSITION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2019-09-12 | — | — | US | claimed |
| WO-2017212329-A1 | CLIPTAC COMPOSITION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2017-12-14 | — | — | WO | claimed |
| EP-0145337-B1 | ELECTROCHROMIC DEVICES | CHEVRON RESEARCH AND TECHNOLOGY COMPANY (US) | 1990-08-08 | — | — | EP | claimed |
| EP-0096723-B1 | BATTERIES FABRICATED WITH ELECTROACTIVE POLYMERS | CHEVRON RESEARCH AND TECHNOLOGY COMPANY (US) | 1988-08-10 | — | — | EP | claimed |
| US-4613211-A | REVERSE COLOR CHANGING POLYMER FILM AS DISPLAY ELECTRODE | CHEVRON RESEARCH COMPANY (US) | 1986-09-23 | — | — | US | claimed |
| US-4579679-A | Electroactive polymers | CHEVRON RESEARCH COMPANY (US) | 1986-04-01 | — | — | US | claimed |
| EP-0145337-A2 | Electrochromic devices | CHEVRON RESEARCH AND TECHNOLOGY COMPANY (US) | 1985-06-19 | — | — | EP | claimed |
| US-4010265-A | DIURETICS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JA) | 1977-03-01 | — | — | US | claimed |
| US-4005201-A | DIURETICS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JA) | 1977-01-25 | — | — | US | claimed |
| US-3998822-A | DIURETICS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JA) | 1976-12-21 | — | — | US | claimed |
| US-3948908-A | Pyridopyridazine derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JA) | 1976-04-06 | — | — | US | claimed |
| US-20260042757-A1 | PYRIDAZINE COMPOUNDS FOR INHIBITING NLRP3 | VENTUS THERAPEUTICS U S INC (US) | 2026-02-12 | — | — | US | disclosed |
| EP-4642772-A1 | NLRP3 INFLAMMASOME INHIBITORS | Astrazeneca AB (SE) | 2025-11-05 | — | — | EP | disclosed |
| EP-4612150-A1 | BRIDGED BICYCLIC HETEROCYCLOALKYL PYRIDO-[3,4-D]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 INHIBITORS | Ventus Therapeutics U.S., Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| US-4017490-A | Pyrido (3,4-d)pyridazines | TAKEDA CHEMICAL INDUSTRIES, LTD. (JA) | 1977-04-12 | — | — | US | disclosed |
| US-3998822-A | DIURETICS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JA) | 1976-12-21 | — | — | US | disclosed |
| US-3948908-A | Pyridopyridazine derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JA) | 1976-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260042757-A1 | PYRIDAZINE COMPOUNDS FOR INHIBITING NLRP3 | NLRP3, NLRP1, PYCARD | CYP19A1 4736/4885PRKCZ 1549/4885MAPT 81/4885 |
| US-11786600-B2 | Cliptac composition | UBE3C, CBLC, STUB1 | CYP19A1 3989/4885PRKCZ 1351/4885MAPT 865/4885 |
| US-20190275161-A1 | CLIPTAC COMPOSITION | UBE3C, CBLC, STUB1 | CYP19A1 3989/4885PRKCZ 1351/4885MAPT 865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.