SCHEMBL140144

SCHEMBL140144

c1cc2ccncc2cn1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCZ Q05513 1/20 0.48
LMNA P02545 2/20 0.42
CYP1A2 P05177 2/20 0.42
CYP3A4 P08684 2/20 0.42
KDM4E B2RXH2 2/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
MAPKAPK2 P49137 1/20 0.42
MELK Q14680 1/20 0.42
PDE3B Q13370 1/20 0.41
PDE3A Q14432 1/20 0.41
CSNK1D P48730 1/20 0.40
CSNK1E P49674 1/20 0.40
CLK1 P49759 1/20 0.40
DYRK1A Q13627 1/20 0.40
CYP19A1 P11511 2/20 0.39
TBXAS1 P24557 1/20 0.39
IMPDH2 P12268 2/20 0.39
MAPT P10636 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31613470 1.00 PRKCZ (0.48) PRKCZLMNACYP1A2CYP3A4KDM4E
SCHEMBL14856279 0.97 PRKCZ (0.46) PRKCZLMNACYP1A2CYP3A4KDM4E
SCHEMBL28235047 0.97 PRKCZ (0.46) PRKCZLMNACYP1A2CYP3A4KDM4E
Benzene SCHEMBL27941073 0.94 PRKCZ (0.45) PRKCZLMNACYP1A2CYP3A4KDM4E
SCHEMBL152013 0.89 CYP19A1 (0.45) PRKCZLMNACYP1A2CYP3A4KDM4E
Hydrochloric Acid SCHEMBL38666248 0.86 CYP19A1 (0.43) PRKCZLMNACYP1A2CYP3A4KDM4E
SCHEMBL27654436 0.86 CYP19A1 (0.43) PRKCZLMNACYP1A2CYP3A4KDM4E
Bromide SCHEMBL30097072 0.86 CYP19A1 (0.43) PRKCZLMNACYP1A2CYP3A4KDM4E
SCHEMBL89121 0.84 CYP19A1 (0.39) PRKCZLMNACYP1A2CYP3A4KDM4E
Naphthalene SCHEMBL7327012 0.84 TNF (0.48) PRKCZLMNACYP1A2CYP3A4KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1994 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12359118-B2 Organic light-emitting device SAMSUNG DISPLAY CO., LTD. (KR) 2025-07-15 US claimed
US-20250075265-A1 ENHANCEMENT OF NUCLEIC ACID POLYMERIZATION BY AROMATIC COMPOUNDS ROCHE SEQUENCING SOLUTIONS INC (US) 2025-03-06 US claimed
US-12232416-B2 Organic light-emitting device SAMSUNG DISPLAY CO., LTD. (KR) 2025-02-18 US claimed
WO-2025023698-A1 NOVEL COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE COMPRISING SAME 주식회사 진웅산업 2025-01-30 WO claimed
US-20250011293-A1 LEUKOTRIENE SYNTHESIS INHIBITORS NAEGIS PHARMACEUTICALS INC. (CA) 2025-01-09 US claimed
EP-3432380-B1 ORGANIC LIGHT-EMITTING DEVICE SAMSUNG DISPLAY CO LTD (KR) 2024-09-25 EP claimed
US-11970731-B2 Enhancement of nucleic acid polymerization by aromatic compounds Roche Sequencing Solutions, Inc. (US) 2024-04-30 US claimed
WO-2023180189-A1 MPRO TARGETING ANTIVIRAL COMPOUNDS EXSCIENTIA AI LIMITED (GB) 2023-09-28 WO claimed
WO-2023172135-A1 AZANAPHTHALENE-FUNCTIONALIZED POLYMERS FOR GENE AND DRUG DELIVERY 20MED THERAPEUTICS B.V. (NL) 2023-09-14 WO claimed
US-11696499-B2 Organic light-emitting device SAMSUNG DISPLAY CO., LTD. (KR) 2023-07-04 US claimed
US-20150060796-A1 ORGANIC LIGHT EMITTING DEVICE SAMSUNG DISPLAY CO., LTD. (KR) 2015-03-05 US claimed
EP-2307422-B1 NOVEL SPIROCHROMANONE CARBOXYLIC ACIDS MSD KK (JP) 2014-03-26 EP claimed
JP-2011526584-A 2011-10-13 JP claimed
EP-2307422-A1 NOVEL SPIROCHROMANONE CARBOXYLIC ACIDS Banyu Pharmaceutical Co., Ltd. (JP) 2011-04-13 EP claimed
US-20110077262-A1 NOVEL SPIROCHROMANONE CARBOXYLIC ACIDS MSD K.K. (JP) 2011-03-31 US claimed
US-7645770-B2 Phenylalanine enamide derivatives UCB PHARMA S.A. (BE) 2010-01-12 US claimed
WO-2010002010-A1 NOVEL SPIROCHROMANONE CARBOXYLIC ACIDS BANYU PHARMACEUTICAL CO.,LTD. (JP) 2010-01-07 WO claimed
WO-2000078726-A1 IMIDAZOLINE DERIVATIVES FOR THE TREATMENT OF DIABETES, ESPECIALLY TYPE II DIABETES ELI LILLY AND COMPANY (US) 2000-12-28 WO claimed
CN-1046270-C Pyrimidine-thloalkyl and alkylether compounds PHARMACIA UPJOHN COMPANY (US) 1999-11-10 CN claimed
CN-1134697-A Pyrimidine-sulfanyl and alkyl ether compounds UPJOHN CO (US) 1996-10-30 CN claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110077262-A1 NOVEL SPIROCHROMANONE CARBOXYLIC ACIDS CNKSR1, CBR1, CBR3 PRKCZ 2726/4885LMNA 1932/4885CYP1A2 839/4885
US-20250011293-A1 LEUKOTRIENE SYNTHESIS INHIBITORS LTC4S, LTB4R2, LTA4H PRKCZ 3787/4885LMNA 970/4885CYP1A2 502/4885
US-11970731-B2 Enhancement of nucleic acid polymerization by aromatic compounds POLN, POLB, POLRMT PRKCZ 4634/4885LMNA 321/4885CYP1A2 1000/4885
US-20250075265-A1 ENHANCEMENT OF NUCLEIC ACID POLYMERIZATION BY AROMATIC COMPOUNDS POLN, POLB, POLRMT PRKCZ 4634/4885LMNA 321/4885CYP1A2 1000/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.