Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.36 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.36 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.36 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.34 |
| ▸ | KDM6B | O15054 | 2/20 | 0.34 |
| ▸ | KDM5C | P41229 | 2/20 | 0.34 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.34 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL5426323 | 0.90 | THRB (0.61) | THRBTSHRPOLBAPEX1HTT | |
| Acetic Acid SCHEMBL2590428 | 0.90 | THRB (0.55) | THRBTSHRPOLBAPEX1HTT | |
| SCHEMBL6864388 | 0.89 | THRB (0.59) | THRBTSHRPOLBAPEX1HTT | |
| SCHEMBL29229747 | 0.89 | THRB (0.59) | THRBTSHRPOLBAPEX1HTT | |
| SCHEMBL14886 | 0.89 | — | — | |
| Methacrylic Acid SCHEMBL467445 | 0.88 | THRB (0.53) | THRBTSHRPOLBAPEX1HTT | |
| Benzene SCHEMBL28116485 | 0.88 | THRB (0.53) | THRBTSHRPOLBAPEX1HTT | |
| Methacrylic Acid SCHEMBL9453862 | 0.88 | THRB (0.53) | THRBTSHRPOLBAPEX1HTT | |
| Succinic Acid SCHEMBL28866675 | 0.88 | THRB (0.53) | THRBTSHRPOLBAPEX1HTT | |
| Ethylene SCHEMBL629900 | 0.87 | THRB (0.57) | THRBTSHRPOLBAPEX1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 150 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215194-A1 | ENHANCED REMOVABILITY OF NAIL COATINGS USING ACIDIC COPOLYMERS FOR TRIGGERED REMOVAL WITH AQUEOUS BASED REMOVER | ARKEMA FRANCE (FR) | 2025-10-16 | — | — | WO | claimed |
| CN-108463209-B | Nail compositions with end-capped oligomers | 露华浓消费品公司 | 2021-09-17 | — | — | CN | claimed |
| EP-3029114-B1 | SYSTEM FOR COVERING A NAIL SURFACE | CREATIVE NAIL DESIGN INC (US) | 2021-03-03 | — | — | EP | claimed |
| US-20210046105-A1 | COMPOSITIONS AND METHODS FOR TARGETING CELLS | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2021-02-18 | — | — | US | claimed |
| US-10632060-B2 | Nail composition with capped oligomers | REVLON CONSUMER PRODUCTS CORPORATION (US) | 2020-04-28 | — | — | US | claimed |
| WO-2019191650-A1 | COMPOSITIONS AND METHODS FOR TARGETING CELLS | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2019-10-03 | — | — | WO | claimed |
| US-20190151223-A1 | ONE PART ARTIFICIAL NAIL COMPOSITIONS | MYCONE DENTAL SUPPLY CO INC (US) | 2019-05-23 | — | — | US | claimed |
| US-20190151222-A1 | ONE PART ARTIFICIAL NAIL SCULPTING COMPOSITIONS AND METHODS WITHOUT REACTIVE OLIGOMERS | NAIL ALLIANCE, LLC | 2019-05-23 | — | — | US | claimed |
| US-20190125652-A1 | One Part Acrylic Nail Formulation | MYCONE DENTAL SUPPLY CO INC (US) | 2019-05-02 | — | — | US | claimed |
| CN-105324103-B | Nail coatings with enhanced adhesion | 指甲创意设计股份有限公司 | 2018-07-20 | — | — | CN | claimed |
| EP-2683350-A1 | COMPOSITIONS AND METHODS FOR UV-CURABLE COSMETIC NAIL COATINGS | Creative Nail Design, Inc. (US) | 2014-01-15 | — | — | EP | claimed |
| US-8541482-B2 | Removable multilayer nail coating system and methods therefore | CREATIVE NAIL DESIGN, INC. (US) | 2013-09-24 | — | — | US | claimed |
| US-8492454-B2 | Removable color layer for artificial nail coatings and methods therefore | CREATIVE NAIL DESIGN, INC. (US) | 2013-07-23 | — | — | US | claimed |
| US-8399537-B2 | Compositions and methods for nail coatings | CREATIVE NAIL DESIGN, INC. (US) | 2013-03-19 | — | — | US | claimed |
| US-8367742-B2 | Removable color layer for artificial nail coatings and methods therefore | CREATIVE NAIL DESIGN, INC. (US) | 2013-02-05 | — | — | US | claimed |
| WO-2012121704-A1 | COMPOSITIONS AND METHODS FOR UV-CURABLE COSMETIC NAIL COATINGS | CREATIVE NAIL DESIGN, INC. (US) | 2012-09-13 | — | — | WO | claimed |
| US-20120083547-A1 | REMOVABLE COLOR LAYER FOR ARTIFICIAL NAIL COATINGS AND METHODS THEREFORE | Creative Nail Disign, Inc. (US) | 2012-04-05 | — | — | US | claimed |
| US-20110274633-A1 | COMPOSITIONS AND METHODS FOR UV-CURABLE COSMETIC NAIL COATINGS | COLOMER USA (US) | 2011-11-10 | — | — | US | claimed |
| US-20110081306-A1 | REMOVABLE COLOR LAYER FOR ARTIFICIAL NAIL COATINGS AND METHODS THEREFORE | CREATIVE NAIL DESIGN, INC. (US) | 2011-04-07 | — | — | US | claimed |
| US-20110082228-A1 | REMOVABLE PROTECTIVE TOPCOAT FOR ARTIFICIAL NAIL COATINGS AND METHODS THEREFORE | CREATIVE NAIL DESIGN, INC. (US) | 2011-04-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190151223-A1 | ONE PART ARTIFICIAL NAIL COMPOSITIONS | POLR1C, PIK3C3, NACA | THRB 1902/4885TSHR 1716/4885POLB 509/4885 |
| US-20190151222-A1 | ONE PART ARTIFICIAL NAIL SCULPTING COMPOSITIONS AND METHODS WITHOUT REACTIVE OLIGOMERS | POLR1C, NACA, SUCLG1 | THRB 732/4885TSHR 1396/4885POLB 237/4885 |
| US-20210046105-A1 | COMPOSITIONS AND METHODS FOR TARGETING CELLS | CD47, CD44, CX3CR1 | THRB 3104/4885TSHR 3778/4885POLB 4111/4885 |
| US-20190125652-A1 | One Part Acrylic Nail Formulation | POLR1C, NACA, PIK3C3 | THRB 2500/4885TSHR 3359/4885POLB 265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.