Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | TYMS | P04818 | 2/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6703429 | 0.81 | DHFR (0.65) | SIRT6MAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8913183 | 0.81 | DHFR (0.44) | POLBTYMSDHFR | |
| SCHEMBL15271381 | 0.72 | SIRT6 (0.81) | SIRT6MAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6151230 | 0.72 | SIRT6 (0.81) | SIRT6MAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL12240580 | 0.71 | SIRT6 (0.74) | SIRT6MAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8912815 | 0.70 | TSHR (0.57) | ALDH1A1LMNASMN1; SMN2TYMSHTT | |
| SCHEMBL8911693 | 0.69 | TTR (0.47) | ALDH1A1POLBDHFR | |
| SCHEMBL8912282 | 0.69 | DRD4 (0.43) | ALDH1A1DHFR | |
| SCHEMBL10651835 | 0.69 | DHFR (0.46) | SIRT6MAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL1646189 | 0.69 | MEN1 (0.61) | SIRT6MAPTALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670508-A | ANTITUMOR AGENTS FOR BRAIN TUMORS | NATIONAL SCIENCE COUNCIL (TW) | 1997-09-23 | — | — | US | disclosed |